Overview
| Uniprot ID | A0A287BJI6 |
|---|
| Protein Name | Serine--tRNA ligase, cytoplasmic |
|---|
| Gene Name | SARS1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 12 |
LDLFRVDKGGDPALI |
| 123 |
KCDAERIKLEAERFE |
| 154 |
NDEDADNKVERIWGD |
| 257 |
VIGKGSEKSDDNSYE |
| 28 |
ESQEKRFKDPGLVDQ |
| 323 |
FRVHQFEKIEQFVYS |
| 478 |
KGIVVPEKLKEFMPP |
| 55 |
FRADNLNKLKNLCSR |
| 57 |
ADNLNKLKNLCSRTI |
Function
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA
Protein Sequence
10
MVLDLDLFRV
20
DKGGDPALIR
30
ESQEKRFKDP
40
GLVDQLVKAD
50
SEWRRCRFRA
60
DNLNKLKNLC
70
SRTIGEKMKK
80
KEAVGNDESL
90
PEDVLNLDDL
100
TADTLTNLKV
110
AQIKKVRLLI
120
DEAILKCDAE
130
RIKLEAERFE
140
NLREIGNLLH
150
PSVPISNDED
160
ADNKVERIWG
170
DCSVRKKYSH
180
VDLVVMVDGF
190
EGEKGAVVAG
200
SRGYFLKGVL
210
VFLEQALIQY
220
ALRTLGSRGY
230
TPIYTPFFMR
240
KEVMQEVAQL
250
SQFDEELYKV
260
IGKGSEKSDD
270
NSYEEKYLIA
280
TSEQPIAALH
290
RDEWLRPEDL
300
PIKYAGLSTC
310
FRQEVGSHGR
320
DTRGIFRVHQ
330
FEKIEQFVYS
340
SPHDNKSWEM
350
FEEMIGTAEE
360
FYQSLGIPYH
370
IVNIVSGSLN
380
HAASKKLDLE
390
AWFPGSGAFR
400
ELVSCSNCTD
410
YQARRLRIRY
420
GQTKKMMDKI
430
KSNPMSTQNK
440
LEAVPSFFSP
450
KKVEFVHMLN
460
ATMCATTRTI
470
CAILENYQTE
480
KGIVVPEKLK
490
EFMPPGLQEL
500
IPFVKPAPID
510
QEPSKKQKKQ
520
HEGSKKKGGA
530
REVALESQLQ
SLEVTDA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0098619 |
selenocysteine-tRNA ligase activity |
| Molecular Function |
GO:0004828 |
serine-tRNA ligase activity |
| Biological Process |
GO:0002181 |
cytoplasmic translation |
| Biological Process |
GO:0016525 |
negative regulation of angiogenesis |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:1904046 |
negative regulation of vascular endothelial growth factor production |
| Biological Process |
GO:0001514 |
selenocysteine incorporation |
| Biological Process |
GO:0006434 |
seryl-tRNA aminoacylation |
| Biological Process |
GO:0106217 |
tRNA C3-cytosine methylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.