Search Results

Overview

Uniprot IDA0A287BJL8
Protein NameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Gene NamePLOD2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
206 KIYIDPLKREALNIT
351 NIKVFFDKAKHEITT
353 KVFFDKAKHEITTIK
406 LTNPRTLKILIEQNR
414 ILIEQNRKIIAPLVT
91 NTIGGGQKVRLMKEV

Function

Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

Protein Sequence

10 MGWCTIRPQQ 20 LLLLVVLVLQ 30 PWNSCLGADS 40 EKPSIIPTDK 50 LLVITVATKE 60 SDGFHRFMQS 70 AKYFNYTVKV 80 LGQGEEWRGG 90 DGINTIGGGQ 100 KVRLMKEVME 110 NYANQEDLII 120 LFTECFDVIF 130 AGGPEEVLKK 140 FQKSNHKVVF 150 SADGILWPDK 160 RLADKYPIVH 170 IGKRYLNSGG 180 FIGYAPYINR 190 IVQQWNLQDN 200 DDDQLFYTKI 210 YIDPLKREAL 220 NITLDHKCKI 230 FQTLNGAVDE 240 VVLKFENGKA 250 RAKNVFYETL 260 PVAINGNGPT 270 KILLNYFGNY 280 VPNAWTQDNG 290 CTLCDVDTID 300 LSAVDVHPNV 310 TIGVFIEQPT 320 PFLPRFLDTL 330 LTLDYPKEAL 340 KLFIHNKEVY 350 HEKNIKVFFD 360 KAKHEITTIK 370 IVGPEENLSQ 380 AEARNMGMDF 390 CRQDENCNYY 400 FSVDADVVLT 410 NPRTLKILIE 420 QNRKIIAPLV 430 TRHGKLWSNF 440 WGALSPDGYY 450 ARSEDYVDIV 460 QGNRVGIWNV 470 PYMANVYLIK 480 GKTLRSEMNE 490 RNYFVRDKLD 500 PDMALCRNAR 510 EMGVFMYVSN 520 RHEFGRLLST 530 ANYNISHYHN 540 DLWQIFENPV 550 DWKEKYINRD 560 YSKIFTENIV 570 EQPCPDVFWF 580 PIFSEKACDE 590 LVEEMEHYGQ 600 WSGGKHHDSR 610 ISGGYENVPT 620 DDIHMKQIDL 630 ENVWLHFIRE 640 FIAPVTLKVF 650 AGYYTKGFAL 660 LNFVVKYSPE 670 RQRSLRPHHD 680 ASTFTINIAL 690 NNVGEDFQGG 700 GCKFLRYNCS 710 IESPRKGWSF 720 MHPGRLTHLH 730 EGLPVKNGTR YIAVSFIDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030867 rough endoplasmic reticulum membrane
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0031418 L-ascorbic acid binding
Molecular Function GO:0008475 procollagen-lysine 5-dioxygenase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.