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Overview

Uniprot IDA0A287BJZ2
Protein NameUbiquitin-protein ligase E3A
Gene NameUBE3A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
50 ELYKINAKLCDPHPS
793 APVGGLGKLKMIIAK

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates

Protein Sequence

10 MFERYYHQLT 20 EGCGNEACTN 30 EFCASCPTFR 40 RMDNNAAAIK 50 ALELYKINAK 60 LCDPHPSKKG 70 ASSAYLENSK 80 GAPNNCSDIK 90 MNRKEGQGAR 100 DDFKDVTYLT 110 EETVYEILEL 120 CREREDYSPL 130 IRVIGRVFSS 140 AEALVQSFRK 150 VKQHTKEELK 160 SLQGKDEDKD 170 EDEKEKAACS 180 AAAMEEDSEA 190 SSSRISDGSQ 200 GDNNLQKLGP 210 DDVSVDIEAI 220 RRVYIRLLSN 230 EKIETAFLNA 240 LVYLSPNVEC 250 DLTYHNVYSR 260 DPNYLNLFII 270 VMENRNLHSP 280 EYLEMALPLF 290 CKAMSKLPLA 300 AQGKLVRLWS 310 KYNADQIRRM 320 METFQQLITY 330 KVISTDFNNR 340 NLVNDDDAIV 350 AASKCLKMVY 360 YANVVGGEVD 370 TNHNEEDDEE 380 PIPESSELTL 390 QELLGEERRN 400 KKGPRVDPLE 410 TELGVKTLDC 420 RKPLIPFEEF 430 INEPLNDVLE 440 MDKDYTFFKV 450 ETENKFSFMT 460 CPFILNAVTK 470 NLGLYYDNRI 480 RMYSERRITV 490 LYSLVQGQQL 500 NPYLRLKVRR 510 DHIIDDALVR 520 LEMIAMENPA 530 DLKKQLYVEF 540 EGEQGVDEGG 550 VSKEFFQLVV 560 EEIFNPDIGM 570 FTYDESTKLF 580 WFNPSSFETE 590 GQFTLIGIVL 600 GLAIYNNCIL 610 DVHFPMVVYR 620 KLMGKKGTFR 630 DLGDSHPVLY 640 QSLKDLLEYE 650 GSVEDDMMIT 660 FQISQTDLFG 670 NPMMYDLKEN 680 GDKIPITNEN 690 RKEFVNLYSD 700 YILNKSVEKQ 710 FKAFRRGFHM 720 VTNESPLKYL 730 FRPEEIELLI 740 CGSRNLDFQA 750 LEETTEYDGG 760 YTRDSVVIRE 770 FWEIVHSFTD 780 EQKRLFLQFT 790 TGTDRAPVGG 800 LGKLKMIIAK NGPDTER

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0048513 animal organ development
Biological Process GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway
Biological Process GO:0010604 positive regulation of macromolecule metabolic process
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0080090 regulation of primary metabolic process
Biological Process GO:0048511 rhythmic process
Biological Process GO:0048731 system development
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.