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Overview

Uniprot IDA0A287BK74
Protein NameEukaryotic translation initiation factor 3 subunit L
Gene NameEIF3L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
250 YRCKTAKKSEEEIDF
344 LENIELNKKSMYSRV
537 RIQLLVFKHKMKNLV
592 FFIRQIHKFEELNRT

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

Protein Sequence

10 VAEGPGRASG 20 FPANSRWAGL 30 PASRRRRGAL 40 FPLFPPGPRS 50 AAAMSYPADD 60 YESETAYDPY 70 AYPGDYDMHT 80 GDPKQDLAYE 90 RQYEQQTYQV 100 IPEVIKNFIQ 110 YFHKTVSDLI 120 DQKVYELQAS 130 RVSSDVIDQK 140 VYEIQDIYEN 150 SWTKLTERFF 160 KNTPWPEAET 170 IAPQVGNDAV 180 FLILYKELYY 190 RHIYAKVSGG 200 PSLEQRFESY 210 YNYCNLFNYI 220 LNADGPAPLE 230 LPNQWLWDII 240 DEFIYQFQSF 250 SQYRCKTAKK 260 SEEEIDFLRS 270 NPKIWNVHSV 280 LNVLHSLVDK 290 SNINRQLEVY 300 TSGGDPESVA 310 GEYGRHSLYK 320 MLGYFSLVGL 330 LRLHSLLGDY 340 YQAIKVLENI 350 ELNKKSMYSR 360 VPECQVTTYY 370 YVGFAYLMMR 380 RYQDAIRVFA 390 NILLYIQRTK 400 SMFQRTTYKY 410 EMINKQNEQM 420 HALLAIALTM 430 YPMRIDESIH 440 LQLREKYGDK 450 MLRMQKGDPQ 460 VYEELFSYSC 470 PKFLSPVVPN 480 YDNVHPNYHK 490 EPFLQQLKVF 500 SDEVQQQAQL 510 STIRSFLKLY 520 TTMPVAKLAG 530 FLDLTEQEFR 540 IQLLVFKHKM 550 KNLVWTSGIS 560 ALDGEFQSAS 570 EVDFYIDKDM 580 IHIADTKVAR 590 RYGDFFIRQI 600 HKFEELNRTL KKMGQRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016282 eukaryotic 43S preinitiation complex
Cellular Component GO:0033290 eukaryotic 48S preinitiation complex
Cellular Component GO:0005852 eukaryotic translation initiation factor 3 complex
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0001732 formation of cytoplasmic translation initiation complex

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.