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Overview

Uniprot IDA0A287BK75
Protein NameDual specificity mitogen-activated protein kinase kinase 1
Gene NameMAP2K1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
104 KLIHLEIKPAIRNQI

Function

No function data available.

Protein Sequence

10 MPKKKPTPIQ 20 LNPAPDGSAV 30 NGTSSAETNL 40 EALQKKLEEL 50 ELDEQQRKRL 60 EAFLTQKQKV 70 GELKDDDFEK 80 ISELGAGNGG 90 VVFKVSHKPS 100 GLVMARKLIH 110 LEIKPAIRNQ 120 IIRELQVLHE 130 CNSPYIVGFY 140 GAFYSDGEIS 150 ICMEHMDGGS 160 LDQVLKKAGR 170 IPEQILGKVS 180 IAVIKGLTYL 190 REKHKIMHRD 200 VKPSNILVNS 210 RGEIKLCDFG 220 VSGQLIDSMA 230 NSFVGTRSYM 240 SPERLQGTHY 250 SVQSDIWSMG 260 LSLVEMAVGR 270 YPIPPPDAKE 280 LELMFGCQVE 290 GDAAETPPRP 300 RTPGRPLSSY 310 GMDSRPPMAI 320 FELLDYIVNE 330 PPPKLPSGVF 340 SLEFQDFVNK 350 CLIKNPAERA 360 DLKQLMVHAF 370 IKRSDAEEVD 380 FAGWLCSTIG 390 LNQPSTPTHA AGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004708 MAP kinase kinase activity
Molecular Function GO:0005078 MAP-kinase scaffold activity
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Molecular Function GO:0097110 scaffold protein binding
Biological Process GO:0090398 cellular senescence
Biological Process GO:0038133 ERBB2-ERBB3 signaling pathway
Biological Process GO:0048009 insulin-like growth factor receptor signaling pathway
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0042552 myelination
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:2000641 regulation of early endosome to late endosome transport
Biological Process GO:0090170 regulation of Golgi inheritance
Biological Process GO:0032872 regulation of stress-activated MAPK cascade
Biological Process GO:0014044 Schwann cell development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.