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Overview

Uniprot IDA0A287BKE1
Protein NameEukaryotic translation initiation factor 4 gamma 2
Gene NameEIF4G2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
187 RNVDVYDKRENPLLP
206 QRAIAKIKMLGNIKF
233 SILHKCIKTLLEKKK
271 RLDHERAKSLMDQYF
31 GAPQHYPKTAGNSEF
313 EHHWVPRKAFLDNGP
321 AFLDNGPKTINQIRQ
41 GNSEFLGKTPGQNAQ
491 NPPLIQEKPAKTSKK
701 KLEKELLKQIKLDPS
717 QTIYKWIKDNISPKL
842 ITQEFPGKGKALFQV
87 KVRGILNKLTPEKFD

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases

Protein Sequence

10 VESAIAEGGA 20 SRFSASSGGG 30 GSRGAPQHYP 40 KTAGNSEFLG 50 KTPGQNAQKW 60 IPARSTRRDD 70 NSAANNSANE 80 KERHDAIFRK 90 VRGILNKLTP 100 EKFDKLCLEL 110 LNVGVESKLI 120 LKGVILLIVD 130 KALEEPKYSS 140 LYAQLCLRLA 150 EDAPNFDGPA 160 AEGQPGQKQS 170 TTFRRLLISK 180 LQDEFENRTR 190 NVDVYDKREN 200 PLLPEEEEQR 210 AIAKIKMLGN 220 IKFIGELGKL 230 DLIHESILHK 240 CIKTLLEKKK 250 RVQLKDMGED 260 LECLCQIMRT 270 VGPRLDHERA 280 KSLMDQYFAR 290 MCSLMLSKEL 300 PARIRFLLQD 310 TVELREHHWV 320 PRKAFLDNGP 330 KTINQIRQDA 340 VKDLGVFIPA 350 PMAQGMRSDF 360 FLEGPFMPPR 370 MKMDRDPLGG 380 LADMFGQMPG 390 SGIGTGPGVI 400 QDRFSPTMGR 410 HRSNQLFNGH 420 GGHIMPPTQS 430 QFGEMGGKFM 440 KSQISLRPAQ 450 SFLMNKNQVP 460 KLQPQITMIP 470 PSAQPPRTQT 480 PPLGQTPQLG 490 LKTNPPLIQE 500 KPAKTSKKPP 510 PSKEELLKLT 520 ETVVTEYLNS 530 GNANEAVNGV 540 REMRAPKHFL 550 PEMLSKVIIL 560 SLDRSDEDKE 570 KASSLISLLK 580 QEGIATSDNF 590 MQAFLNVLDQ 600 CPKLEVDIPL 610 VKSYLAQFAA 620 RAIISELVSI 630 SELAQPLESG 640 THFPLFLLCL 650 QQLAKLQDRE 660 WLTELFQQSK 670 VNMQKMLPEI 680 DQNKDRMLEI 690 LEGKGLSFLF 700 PLLKLEKELL 710 KQIKLDPSPQ 720 TIYKWIKDNI 730 SPKLHVDKGF 740 VNILMTSFLQ 750 YISSEVNPPS 760 DETDSSSAPS 770 KEQLEQEKQL 780 LLSFKPVMQK 790 FLHDHVDLQV 800 SALYALQVHC 810 YNSNFPKGML 820 LRFFVHFYDM 830 EIIEEEAFLA 840 WKEDITQEFP 850 GKGKALFQVN 860 QWLTWLETAE EEESEEEAD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0006446 regulation of translational initiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.