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Overview

Uniprot IDA0A287BKE5
Protein NameE3 ubiquitin-protein ligase UHRF
Gene NameUHRF1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
354 ACRLCGGKQDPDKQL
530 AEQSCDQKLTNTNRA
56 NSLSRLTKVENLRRR
590 NRYDGIYKVVRYWPE

Function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications

Protein Sequence

10 HRGAGGVAQA 20 RGAAGRGPRA 30 RGVRSFRVSA 40 GIMWIQVRTM 50 DGKVAHTVNS 60 LSRLTKVENL 70 RRRIQEVFHV 80 EPGLQRLFYR 90 GKQMEDGHTL 100 FDYDVRLNDT 110 IQLLVRQSPI 120 SSKERDSELS 130 DTDSGCCLGQ 140 SESDKSSNSG 150 EAANEPEVKA 160 DEDTWDETEL 170 GLYKAGEYVD 180 ARDTNMGAWF 190 EAQVIRVTKK 200 TVAQDRPCSS 210 SSSSSSTLED 220 DVIYHVKYED 230 YPENGVVQLS 240 SRDVRARARQ 250 ILKWHELEVG 260 QVVMLNYNTD 270 SPKDRGFWYD 280 AEILRKRETR 290 TARELHANVR 300 IGDDSLNDCR 310 IIFVDEVFKI 320 ERPGEGSPLV 330 ETPVRRKSGP 340 TCKHCKDNPR 350 KLCRMCACRL 360 CGGKQDPDKQ 370 LMCDECDMAF 380 HMYCLCPPLS 390 SVPSEAEWYC 400 PECRIDSSEV 410 VQAGEKLKES 420 KKKAKMASAT 430 SSSQRDWGKG 440 MACVGRTKEC 450 TIVPSNHYGP 460 IPGIPVGTMW 470 RFRVQVSESG 480 VHRPHVAGIH 490 GRSNDGAYSL 500 VLAGGYEDDV 510 DHGNSFTYTG 520 SGGRDLSGNK 530 RTAEQSCDQK 540 LTNTNRALAL 550 NCFAPINDRK 560 GAEAKDWRSG 570 KPVRVVRNVK 580 GRKHSKYAPV 590 EGNRYDGIYK 600 VVRYWPEKGK 610 SGFLVWRFLL 620 RRDDVEPGPW 630 TKEGKDRIKK 640 LGLTMQYPEG 650 YLEALAKKEK 660 EKENKNSKRA 670 AVEEEEEEGR 680 EDFETPRKGK 690 RKSQAAGGGK 700 VSDGPSRGAP 710 KKTKVEPYSL 720 TAQQSSLIKE 730 DKSNTKLWTE 740 ILKSLKDGPK 750 FLSKVEETFQ 760 CICCQELVFR 770 PITTVCQHNV 780 CKDCLDRSFK 790 AQVFSCPACR 800 YNLGRHSTMQ 810 VNQPLQAVLS 820 QLFPGYGNGR

Gene Ontology

Classification GO ID Description
Biological Process GO:0051865 protein autoubiquitination
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005657 replication fork
Molecular Function GO:0000987 cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0044729 hemi-methylated DNA-binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140851 histone H3K14 ubiquitin ligase activity
Molecular Function GO:0140248 histone H3K18 ubiquitin ligase activity
Molecular Function GO:0140234 histone H3K23 ubiquitin ligase activity
Molecular Function GO:0062072 histone H3K9me2/3 reader activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008327 methyl-CpG binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0141119 chromosomal DNA methylation maintenance following DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071168 protein localization to chromatin
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0050678 regulation of epithelial cell proliferation
Biological Process GO:0006950 response to stress
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.