Search Results
Overview
| Uniprot ID | A0A287BKR2 |
|---|---|
| Protein Name | Serine hydroxymethyltransferase |
| Gene Name | SHMT2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | YSEGYPGKRYYGGAE |
| 281 | VVTTTTHKTLRGARS |
| 356 | EYSLQVLKNARAMAD |
| 464 | EVKSKTTKLQDFKSF |
| 469 | TTKLQDFKSFLLKDP |
| 474 | DFKSFLLKDPETCRR |
Function
Interconversion of serine and glycine
Protein Sequence
10
MMLPFPFLWA
20
TRPLWRCGQL
30
VKMAIRSQHS
40
EAAQTQTGEA
50
TKGWSGQESL
60
SDSDPEMWEL
70
LRREKDRQCR
80
GLELIASENF
90
CSRAALEALG
100
SCLNNKYSEG
110
YPGKRYYGGA
120
EVVDEIELLC
130
QRRALEAFDL
140
DPAQWGVNVQ
150
PYSGSPANLA
160
AYTALLQPHD
170
RIMGLDLPDG
180
GHLTHGYMTD
190
VKRISATSIF
200
FESMPYKLNP
210
KTGLIDYDQL
220
ALTARLFRPR
230
LIIAGTSAYA
240
RLIDYARMRE
250
VCDEVKAHLL
260
ADMAHISGLV
270
AAKVIPSPFE
280
HADVVTTTTH
290
KTLRGARSGL
300
IFYRKGVRTV
310
DPKTGREIPY
320
TFEDRINFAV
330
FPSLGGPHNH
340
AIAAVAVALK
350
QACTPMFREY
360
SLQVLKNARA
370
MADALLERGY
380
SLVSGGTDNH
390
LVLVDLRPKG
400
LDGARVERVL
410
ELVSITANKN
420
TCPGDRSAIT
430
PGGLRLGTPA
440
LTSRQFREDD
450
FRKVVAFIDE
460
GVSIGLEVKS
470
KTTKLQDFKS
480
FLLKDPETCR
490
RLADLRQRVE
500
QFARAFPMPG
FEEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070552 | BRISC complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0004372 | glycine hydroxymethyltransferase activity |
| Molecular Function | GO:0120567 | hydroxytrimethyllysine aldolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0015943 | formate biosynthetic process |
| Biological Process | GO:0019264 | glycine biosynthetic process from L-serine |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0070536 | protein K63-linked deubiquitination |
| Biological Process | GO:0070129 | regulation of mitochondrial translation |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:0034340 | response to type I interferon |
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
| Biological Process | GO:0046653 | tetrahydrofolate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.