Overview
| Uniprot ID | A0A287BKT5 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 3 |
|---|
| Gene Name | PTBP3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 14 |
GNDNKKFKGDRPPCS |
| 390 |
SGQRLYGKVLRATLS |
| 470 |
TEAGCSVKAFKFFQK |
| 473 |
GCSVKAFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MNSITNGNDN
20
KKFKGDRPPC
30
SPSRVLHLRK
40
IPSDVTEAEV
50
ISLGLPFGKV
60
TNLLMLKGKS
70
QAFLEMASEE
80
AAVTMVNYYT
90
PVTPHLRSQP
100
VFIQYSNHRE
110
LKTDNLPNQA
120
RAQAALQAVS
130
AVQSGSLGLP
140
GAPTNEGTIL
150
PGQSPVLRII
160
IENLFYPVTL
170
EVLHQIFSKF
180
GTVLKIITFT
190
KNNQFQALLQ
200
YADPLNAHYA
210
KMALDGQNIY
220
NACCTLRIDF
230
SKLTSLNVKY
240
NNDKSRDFTR
250
LDLPTGDGQP
260
SLEPPMAAAF
270
GAPGIISSPY
280
AGAAGFAPAI
290
GFPQATGLSV
300
PAGLGPGALG
310
PLAITSSAVT
320
GRMAMPGTGG
330
IPGNSVLLVT
340
NLNPDLVTPH
350
GLFILFGVYG
360
DVHRVKIMFN
370
KKENALVQMA
380
DANQAQLAMN
390
HLSGQRLYGK
400
VLRATLSKHQ
410
AVQLPREGQE
420
DQGLTKDFSN
430
SPLHRFKKPG
440
SKNFQNIFPP
450
SATLHLSNIP
460
PSVTVDDLKN
470
LFTEAGCSVK
480
AFKFFQKDRK
490
MALIQLGSVE
500
EAIQALIELH
510
NHDLGENHHL
RVSFSKSTI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0043249 |
erythrocyte maturation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.