Search Results
Overview
| Uniprot ID | A0A287BKY8 |
|---|---|
| Protein Name | Filamin-binding LIM protein 1 |
| Gene Name | FBLIM1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 284 | CYQDTLEKCGKCGEG |
| 287 | DTLEKCGKCGEGVRE |
| 340 | CLDDFYRKFAPVCSI |
| 403 | LNNRLFCKPCHVKRS |
| 87 | RESPVPVKAPGAGSA |
Function
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion
Protein Sequence
10
MTFGAPSVAG
20
WVAAPPHPEP
30
CPRLSPTLSP
40
APPGAKAMAS
50
KPEKRVASSV
60
FITLAPPRRD
70
EAVVEEVKRA
80
ACEARPGCPR
90
ESPVPVKAPG
100
AGSAGRLRSW
110
APPGRASAPV
120
PAVPPQLSNG
130
GCSLPPPPLD
140
GEDSLPDLDL
150
LPPPPPPPPP
160
MYLPPPDQEP
170
PASVGALVSD
180
LEQLHLPPPP
190
PPPQALVEGP
200
PLQPQPSPLR
210
PMEELPPPPE
220
EPVSLPEREA
230
STDICAFCHK
240
TVSPRELAVE
250
AMKRQYHAQC
260
FTCRVCRRQL
270
AGQSFYQKDG
280
RPLCEPCYQD
290
TLEKCGKCGE
300
GVREHIIRAL
310
GQAFHPTCFT
320
CVTCARCIGD
330
ESFALDSQNE
340
VYCLDDFYRK
350
FAPVCSICEN
360
PIIPRDGKDA
370
FKIECMGRNF
380
HENCYRCEDC
390
RILLSVEPTD
400
QGCYPLNNRL
410
FCKPCHVKRS
AASCC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0031005 | filamin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0033623 | regulation of integrin activation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.