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Overview

Uniprot IDA0A287BLH2
Protein NameC-Jun-amino-terminal kinase-interacting protein 4
Gene NameSPAG9
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1000 CLHSIKLKDSILSIV
1067 VWCGYRNKIYVVQPK
603 LSQLPGDKSKAFDFL

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking

Protein Sequence

10 MELEDGVVYQ 20 EEPGGSGAVM 30 SERVSGLAGS 40 IYREFERLIG 50 RYDEEVVKEL 60 MPLVVAVLEN 70 LDSVFAQDQE 80 HQVELELLRD 90 DNEQLITQYE 100 REKALRKHAE 110 EKFIEFEDSQ 120 EQEKKDLQTR 130 VESLESQTRQ 140 LELKAKNYAD 150 QISRLEEREA 160 ELKKEYNALH 170 QRHTEMIHNY 180 MEHLERTKLH 190 QLSGSDQLES 200 TAHSRIRKER 210 PISLGIFPLP 220 AGEGLLTPDT 230 QKGGETPGSE 240 QWKFQELSQP 250 RSHTSLKVSS 260 SPEPLKAIEQ 270 EDELSDVSQG 280 GSKATTPAST 290 AASDVAAIPA 300 DTPLNEDNEG 310 FVKVAETPDK 320 SEISKHIEVQ 330 VAQETRNVSI 340 GSAENEEKSE 350 VQAIIESTPE 360 LDMDKDLSGY 370 KGSSTPTKGI 380 ENKAFDRNTE 390 SLFEELSSAG 400 SGLIGDVDEG 410 ADLLGMGREV 420 ENLILENTQL 430 LETKNALNVV 440 KNDLIAKVDE 450 LTCEKDVLQG 460 ELEAVKQAKL 470 KLEEKNKELE 480 EELRKARAEA 490 EDARQKAKDD 500 DDSDIPTAQR 510 KRFTRVEMAR 520 VLMERNQYKE 530 RLMELQEAVR 540 WTEMIRASRE 550 NPAMQEKKRS 560 SIWQFFSRLF 570 SSSSNTTKKP 580 EPPVNLKYNA 590 PTSHVTPSVK 600 KRSSTLSQLP 610 GDKSKAFDFL 620 SEETEASLAS 630 RREQKREQYR 640 QVKAHVQKED 650 GRVQAFGWSL 660 PQKYKQVTNG 670 QGENKMKNLP 680 VPVYLRPLDE 690 KDASMKLWCA 700 VGVNLSGGKT 710 RDGGSVVGAS 720 VFYKDVAGLE 730 SEGSKQRSAS 740 QSSLDKLDQE 750 LKEQQKELKN 760 QEELSSLVWI 770 CTSTHSATKV 780 IIIDAVQPGN 790 ILDSFTVCNS 800 HVLCIASVPG 810 ARETDYPAGE 820 ELSESGQVDK 830 ASLCGSMTSN 840 SSTETDSLLG 850 GITVVGCSTE 860 GVTAVATSPS 870 TNGTSPVTEK 880 PPEKEAENSE 890 VDENVPTAEE 900 ATEATEGNAG 910 SAEDTVDISQ 920 AGVYTEHVFT 930 DPLGVQIPED 940 LSPVYQSSND 950 SDAYKDQISV 960 LPNEQDLVRE 970 EAQKMSSLLP 980 TMWLGAQNGC 990 LYVHSSVAQW 1000 RKCLHSIKLK 1010 DSILSIVHVK 1020 GIVLVALADG 1030 TLAIFHRGVD 1040 GQWDLSNYHL 1050 LDLGRPHHSI 1060 RCMTVVHDKV 1070 WCGYRNKIYV 1080 VQPKAMKIEK 1090 SFDAHPRKES 1100 QVRQLAWVGD 1110 GVWVSIRLDS 1120 TLRLYHAHTY 1130 QHLQDVDIEP 1140 YVSKMLGTGK 1150 LGFSFVRITA 1160 LMVSCNRLWV 1170 GTGNGVIISI 1180 PLTETNKTSG 1190 ASGNRPGSVI 1200 RVYGDENSDK 1210 VTPGTFIPYC 1220 SMAHAQLCFH 1230 GHRDAVKFFV 1240 AVPGQVISPQ 1250 SGSSGTDLTA 1260 DKVGPSAQEP 1270 GSQTPLKSML 1280 VISGGEGYID 1290 FRMGDEGGES 1300 ELLGEDLPLE 1310 PSVTKAERSH 1320 LIVWQVMYGS E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0016301 kinase activity
Molecular Function GO:0005078 MAP-kinase scaffold activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.