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Overview

Uniprot ID	A0A287BM44
Protein Name	Long-chain-fatty-acid--CoA ligase
Gene Name	ACSL1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
475	IQSSLGGKVRLMVTG

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation

Protein Sequence

10 MMQAHELFRY 20 FRMPELVDFQ 30 QYVRTLPTNT 40 LMGFGAFAAL 50 TTFWYATRPR 60 ALKPPCDLAM 70 QSVEVAGSDG 80 ARRSAILDSD 90 EPLAYFYDDV 100 RTLYEGFQRG 110 IRVSNNGPCL 120 GSRKPDQPYE 130 WLSYKQVEDM 140 SECVGSALIH 150 KGFKAGPENF 160 VGIFAQNRPE 170 KDYGRSVKVD 180 LLEVASWRSL 190 EGCEDGEAKG 200 ISETMACLCW 210 GMKHLPVWVI 220 IEQGCFAYSM 230 VVVPLYDTLG 240 TEAITYIINK 250 GELSLVFVDK 260 PEKANLLLEG 270 VENKLIPGLK 280 TIILMDSYGI 290 DLLERGKKCG 300 VEIMSMKALE 310 DLGRANRRKP 320 KPPAPEDLAV 330 ICFTSGTTGN 340 PKGAMITHRN 350 VVSDCSAFVK 360 VTEKTFSPSS 370 DDTLISFLPL 380 AHMFERVVEC 390 VMLCHGAKIG 400 FFQGDIRLLM 410 DDLKALQPTI 420 FPVVPRLLNR 430 MFDRIFGQAN 440 TTLKRWLLDF 450 ASKRKEAELR 460 SGIIRNNSLW 470 DKLIFHKIQS 480 SLGGKVRLMV 490 TGAAPVSATV 500 LTFLRAALGC 510 QFYEGYGQTE 520 CTAGCSLTVP 530 GDWTAGHVGA 540 PMPCSLIKLV 550 DVEEMNYLAA 560 KGEGEVCVKG 570 PNVFQGYLKD 580 PAKTAEALDK 590 DGWLHTGDIG 600 KWLPNGTLKI 610 IDRKKHIFKL 620 AQGEYIAPEK 630 IENIYLRSEP 640 VAQVFVHGES 650 LQAFLIAIVV 660 PDVETLGHWA 670 QKRGFVGSFE 680 ELCRNKDVKK 690 AILEDMLRLG 700 RDAGLKSFEQ 710 VRGISLHPEL 720 FSIDNGLLTP 730 TMKAKRPELR 740 NYFRSQIDEL YSTVKV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding
Cellular Component	GO:0005741	mitochondrial outer membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.