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Overview

Uniprot ID	A0A287BMI6
Protein Name	Mitogen-activated protein kinase kinase kinase kinase
Gene Name	MAP4K5
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
171	KITATIAKRKSFIGT

Function

Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

Protein Sequence

10 MEAPLRPAAD 20 ILRRNPQQDY 30 ELVQRVGSGT 40 YGDVYKARNI 50 HTGELAAVKI 60 IKLEPGDDFS 70 LIQQEIFMVK 80 ECKHCNIVAY 90 FGSYLSREKL 100 WICMEYCGGG 110 SLQDIYHVTG 120 PLSELQIAYV 130 CRETLQGLAY 140 LHTKGKMHRD 150 IKGANILLTD 160 HGDVKLADFG 170 VAAKITATIA 180 KRKSFIGTPY 190 WMAPEVAAVE 200 KNGGYNQLCD 210 IWAVGITAIE 220 LGELQPPMFD 230 LHPMRALFLM 240 SKSNFQPPKL 250 KDKTKWSSTF 260 HNFVKIALTK 270 NPKKRPTAER 280 LLTHTFVGQP 290 GLSRALAVEL 300 LDKVNNPDNH 310 THYTEGDDDD 320 FEPHAIIRHT 330 IRSTNRNARA 340 ERTASEINFD 350 KLQFEPPLRK 360 ETEARDEMGL 370 SSDPNFLLRW 380 NPFVDGANTG 390 KSTSKRAVPP 400 PLPPKPRINS 410 YPEDNLPEEE 420 KSSTVKRCPD 430 SENRAPQVLR 440 RQSSPSCGPV 450 AETSAIGNGD 460 GISKLISENT 470 EGSAQAPQLP 480 RKKDKRDFPK 490 PVINGLPPTP 500 KVLMGACFSK 510 VFDGCPLKIN 520 CATSWIHPDT 530 KDQYIIFGTE 540 DGIYTLNLNE 550 LHEATMEQLF 560 PRKCTWLYVI 570 NNTLMSLSGK 580 TFQLYSHNLI 590 ALFEQAKKPG 600 LAAHIQTHRF 610 PDRILPRKFA 620 LTTKIPDTKG 630 CHKCCIVRNP 640 YTGHKYLCGA 650 LQSGIVLLQW 660 YEPMQKFMLI 670 KHFDFPLPSP 680 LNVFEMLVIP 690 EQEYPMVCVA 700 ISKGTEPNQV 710 VQFETINLNS 720 ASSWFTEIGA 730 GSQQLDSIHV 740 TQLERDTVLV 750 CLDKFVKIVN 760 LQGKLKSSKK 770 LASELSFDFR 780 IESVVCLQDS 790 VLAFWKHGMQ 800 GKSFKSDEVT 810 QEISDETRVF 820 RLLGSDRVVV 830 LESRPTENPT 840 AHSNLYILAG HENSY

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008349	MAP kinase kinase kinase kinase activity
Molecular Function	GO:0106310	protein serine kinase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.