Search Results
Overview
| Uniprot ID | A0A287BMK8 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 265 | RDYPLASKDAKKQLL |
| 269 | LASKDAKKQLLCGAA |
| 465 | FSEADKIKVAQGVSG |
| 477 | VSGAVQDKGSIHKFV |
| 538 | HSLHSYEKRLF**** |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MADYLISGGT
20
SYVPDDGLTA
30
QQLFNCGDGL
40
TYNDFLILPG
50
YIDFTADQVD
60
LTSALTKKIT
70
LKTPLVSSPM
80
DTVTEAGMAI
90
AMALTGGIGF
100
IHHNCTPEFQ
110
ANEVRKVKHP
120
FFPLWGFSSS
130
EEPETLCLKA
140
TEEDQKYEQG
150
FITDPVVLSP
160
KDRVRDVFEA
170
KAQHGFCGIP
180
ITDTGRMGSR
190
LVGIISSRDI
200
DFLKEEEHDR
210
FLEEIMTKRE
220
DLVVAPAGIT
230
LKEANEILQR
240
SKKGKLPIVN
250
EDDELVAIIA
260
RTDLKKNRDY
270
PLASKDAKKQ
280
LLCGAAIGTH
290
EDDKYRLDLL
300
AQAGVDVVVL
310
DSSQGNSIFQ
320
INMIKYIKEK
330
YPSLQVIGGN
340
VVTAAQAKNL
350
IDAGVDALRV
360
GMGSGSICIT
370
QEVLACGRPQ
380
ATAVYKVSEY
390
ARRFGVPVIA
400
DGGIQNVGHI
410
AKALALGAST
420
VMMGSLLAAT
430
TEAPGEYFFS
440
DGIRLKKYRG
450
MGSLDAMDKH
460
LSSQNRYFSE
470
ADKIKVAQGV
480
SGAVQDKGSI
490
HKFVPYLIAG
500
IQHSCQDIGA
510
KSLTQVRAMM
520
YSGELKFEKR
530
TSSAQVEGGV
540
HSLHSYEKRL
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0006183 | GTP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.