Search Results

Overview

Uniprot IDA0A287BNA1
Protein NameProtein 4.1
Gene NameEPB41L2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
232 CDLEKRAKGQVLFDK
270 KNWVDPAKEIKRQLR
373 EKVAELYKTHRGLSP
451 KRSNFYIKVRPAELE
479 RAAKRLWKVCVEHHT
500 PEPPPKAKFLTLGSK
507 KFLTLGSKFRYSGRT
594 RDVRSLAKAPPVQYI
914 QRTEISTKEVPIVQT
968 THITKTVKGGISETR

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTEVGSASE 20 VKKESDQLGA 30 DATKEKPKEV 40 AENQQNQSSD 50 PEEEKGSQSS 60 PPAESQSSSR 70 PQKKERDPSG 80 SRGISRFIPP 90 WLKKQKSYTL 100 VVAKDGGDKK 110 EPTQAVVEEQ 120 ILAKEESLPE 130 EGKQAKGDAA 140 EMALQKQQQI 150 KVDVKEEKPP 160 VSSLEMQPVE 170 EVSKEREEEK 180 GKEIQEDTLD 190 EAAKRETKEV 200 QTNELKAEKA 210 SQKATKKTKT 220 VQCKVTLLDG 230 TEYSCDLEKR 240 AKGQVLFDKV 250 CEHLNLLEKD 260 YFGLVFQENP 270 EQKNWVDPAK 280 EIKRQLRNLP 290 WLFTFNVKFY 300 PPDPSQLTED 310 ITRYFLCLQL 320 RQDIASGRLP 330 CSLMTHALLG 340 SYTLQAELGD 350 YDPEEHDSND 360 LSDFQFAPTQ 370 TKELEEKVAE 380 LYKTHRGLSP 390 AQADSQFLEN 400 AKRLSMYGVD 410 LHHAKDSEGV 420 DIKLGVCANG 430 LLIYKDRLRI 440 NRFAWPKILK 450 ISYKRSNFYI 460 KVRPAELEQF 470 ESTIGFKLPN 480 HRAAKRLWKV 490 CVEHHTFYRL 500 VSPEPPPKAK 510 FLTLGSKFRY 520 SGRTQAQTRQ 530 ASTLIDRPAP 540 HFERTSSKRV 550 SRSLDGAPVG 560 VVDQSLMKDF 570 AGPAGEVSAY 580 GPGVVSPAVV 590 QDGDGRRDVR 600 SLAKAPPVQY 610 IEGKDLDKAQ 620 EEILKHQASI 630 SELKRNFMES 640 TPEPRPNEWE 650 KRRITPLSLQ 660 TQGSKGDRLF 670 KDIFSMKEKH 680 QMAATRTVEE 690 KAQEADKKRA 700 PESEGPCAGA 710 SDAVKSSHET 720 LNVVEEKKQA 730 EVGKDERVIT 740 EEVNGKALAP 750 GRGPGEMRKV 760 EPGTQKDSTS 770 LSSESSPSSE 780 SEDEDVGEYR 790 PHHQVTEGTI 800 REEQEEEEEV 810 EEAPGPAAKV 820 VEREDPVPAT 830 RPVTHAGANV 840 STVETVIQEN 850 VVAPQIPTEK 860 SVNEGVKQDV 870 REDPEDEPQK 880 VNGEVSHVDI 890 DVLPQVICCS 900 EPPVVKTEMV 910 TISDASQRTE 920 ISTKEVPIVQ 930 TETKTITYES 940 PQIDGGAGGD 950 SGTLLTAQTI 960 TSESVSTTTT 970 THITKTVKGG 980 ISETRIEKRI 990 VITGDADIDH 1000 DQALAQAIRE 1010 AREQHPDMSV 1020 TRVVVHKETE LEEGDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.