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Overview

Uniprot IDA0A287BNC1
Protein NameExtended synaptotagmin-2
Gene NameESYT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
179 VYTENVDKRQIILDL
302 QLRFPVPKGVLRIHF
323 QGKDTYLKGLVKGKS
701 RLYLLPDKRRSGRRK

Function

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS)

Protein Sequence

10 MSGPRAPGPE 20 AGAAGAEPPG 30 AALSVDVTGL 40 LAQLARSFAL 50 LLPVYALGYL 60 GLSFSWVLLA 70 LGLLVWCRRS 80 RGLKATRLCR 90 ALALLEDEER 100 AVRLGVRACD 110 LPAWVHFPDT 120 ERAEWLNKTV 130 KHMWPFICQF 140 IEKLFRETIE 150 PAVRGAHPHL 160 STFSFTRVDV 170 GQQPLRINGV 180 KVYTENVDKR 190 QIILDLQISF 200 VGNCEIDLEI 210 KRYFCRAGVQ 220 SIQIHGTMRV 230 ILEPLIGDMP 240 LVGALSIFFL 250 RKPLLEINWT 260 GLTNLLDIPG 270 LNGLSDTIIL 280 DIISNYLVLP 290 NRVTVPLVSE 300 VQIAQLRFPV 310 PKGVLRIHFI 320 EAQDLQGKDT 330 YLKGLVKGKS 340 DPYGVLRVGN 350 QIFQSKVIKE 360 SLSPKWNEVY 370 EALVYEHPGQ 380 ELEIELFDED 390 PDKDDFLGSL 400 MIDLIEVEKE 410 RLLDEWFALD 420 EVPKGKLHLK 430 LEWLTLVPNA 440 VNLEKVLTDI 450 RADKDQATDG 460 LSSSLLILYL 470 DSARNLPVRD 480 EQHQCSLGNL 490 RIPLSQLLAS 500 EDMTMNQRFQ 510 LSNSGPNSSL 520 KMKLALRVLH 530 LEKQERSPDH 540 QHSAQVKRPS 550 VSKEGRKIPV 560 RPQMSASPGT 570 GDSSTAPSSP 580 VVGGGDKPGV 590 EERAPPAEAS 600 PQGPQDLGRS 610 SSSLQASGTG 620 SPSHISVKEP 630 TPSIASDISL 640 PIATQELRQR 650 LRQLENGTTL 660 GQSPLGQIQL 670 TIRHSSQRNK 680 LVVVVHSCRN 690 LIAFSEDGSD 700 PYVRLYLLPD 710 KRRSGRRKTH 720 VSKKTLNPVF 730 DQSFDFSVSL 740 PEAQRRTLDV 750 AVKNSGGFLS 760 KDKGLLGKVL 770 VGLASEELAK 780 GWTQWYDLTE DGTRPHVVT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.