Search Results
Overview
| Uniprot ID | A0A287BNC2 |
|---|---|
| Protein Name | Mitotic spindle assembly checkpoint protein MAD1 |
| Gene Name | MAD1L1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 61 | RAEQIRSKSHLIQVE |
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling
Protein Sequence
10
MEDLGENTTV
20
LSTLRSLNSF
30
ISQRVEGGSG
40
LDVSTPAQGS
50
LQMQYQQSMQ
60
LEERAEQIRS
70
KSHLIQVERE
80
KMQMELSHKR
90
ARVELERAAS
100
TSARSYEREV
110
DRNQELLTRI
120
RQLQEREAEA
130
EEKMKEQLER
140
YRLCQQSLDA
150
ASRKLREEED
160
SLAEAGETIS
170
ALKGRLSELQ
180
WSAMNQEMQV
190
KRLESEKQEL
200
KEQLDLQHKK
210
WQEAQQKVQE
220
LQASQDARAD
230
QEQRIKDLEQ
240
KLSLQEQDAA
250
IVRSMRSELV
260
RLPTMERELR
270
QLREENACLR
280
ETREASGLLR
290
EELEGLQRRL
300
GRQEKLQENL
310
VNLELENERL
320
LTKLQSWERL
330
GQTTGLSISA
340
RGLEKARLQL
350
QEEVRQVSSQ
360
LLEERKKRET
370
HEALARRLQK
380
RVLLLTKERD
390
GMRAILGSYD
400
SELTPAEYAP
410
QLTRRLREAE
420
DMVQKVHAHS
430
SEVEVQLSQA
440
LEELGGQKQR
450
ADALEMELQM
460
LKSQAGPAEQ
470
SFLFSREEVS
480
ALRLKIEELA
490
QERSRLEEDK
500
KLLEAQLERL
510
TLQGDFDQSR
520
TKVLHLSLNP
530
ASVARQRFRE
540
DWQQLQEECK
550
HLRELVRALE
560
AGGPVPADLE
570
AAAGLPSSKE
580
VAELKRQVES
590
AELKNQRLKE
600
VFQTKIQEFR
610
KACYALTGYQ
620
VDITTEGQFR
630
LTSMYAERKA
640
DCLVFKAAGP
650
SGTKMQLLET
660
EFSRTVPELI
670
ELHLLRQDSI
680
PAFLSALTLD
LFSRQTVA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:1990706 | MAD1 complex |
| Cellular Component | GO:1990728 | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0000922 | spindle pole |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.