Search Results
Overview
| Uniprot ID | A0A287BNE4 |
|---|---|
| Protein Name | NEDD8-conjugating enzyme UBC12 |
| Gene Name | UBE2M |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | AAQLRIQKDINELNL |
| 145 | CPDEGFYKSGKFVFS |
| 148 | EGFYKSGKFVFSFKV |
| 94 | EESAGGTKGSSKKAS |
| 99 | GTKGSSKKASAAQLR |
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation
Protein Sequence
10
MPEPSRSSPI
20
PSPTERQGRG
30
AAAATAAAQA
40
HRAVRAGRAE
50
AGRRRKYPKR
60
WGARGRCRPP
70
RRSRRCRGSR
80
HSFRTRPERG
90
SQQKKEEESA
100
GGTKGSSKKA
110
SAAQLRIQKD
120
INELNLPKTC
130
DISFSDPDDL
140
LNFKLVICPD
150
EGFYKSGKFV
160
FSFKVGQGYP
170
HDPPKVKCET
180
MVYHPNIDLE
190
GNVCLNILRE
200
DWKPVLTINS
210
IIYGLQYLFL
220
EPNPEDPLNK
230
EAAEVLQNNR
240
RLFEQNVQRS
250
MRGGYIGSTY
FERCLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061654 | NEDD8 conjugating enzyme activity |
| Molecular Function | GO:0019788 | NEDD8 transferase activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Biological Process | GO:0045116 | protein neddylation |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.