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Overview

Uniprot IDA0A287BNQ9
Protein NameKinesin-like protein
Gene NameKIF23
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
183 REATPNPKTPSSKRQ
642 ETTMKWEKECERRVA
662 MQNKLWVKDEKLKQL
781 EIETKLIKGDVYKTR
786 LIKGDVYKTRGGGQS

Function

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro

Protein Sequence

10 MKPARTKTPR 20 KPPVKKGAQT 30 TLKDPVGVYC 40 RVRPLSLLDQ 50 ECCIEVINNT 60 TVQLHTPEGY 70 RLNRNGDYKE 80 TQYSFKQVFG 90 THTTQKELFD 100 VVANPLVDDL 110 IHGKNGLLFT 120 YGVTGSGKTH 130 TMTGSPGEGG 140 LLPRCLDMIF 150 NSIGSFQAKR 160 YVFKSNDRNS 170 MDIQCEVDAL 180 LERQKREATP 190 NPKTPSSKRQ 200 VDPEFVDMIN 210 VQEFCKAEEV 220 DEDSVYGVFV 230 SYIEIYNNYI 240 YDLLEEVPFD 250 PIKPKWNSCS 260 TPMRNTEFVP 270 PQSKLLREDK 280 NHNMYVAGCT 290 EVEVKSTEEA 300 FEVFWRGQKK 310 RRIANTHLNR 320 ESSRSHSVFN 330 IKLVQAPLDA 340 DGDNVLQEKE 350 QITISQLSLV 360 DLAGSERTNR 370 TKAEGNRLRE 380 AGNINQSLMT 390 LRTCMEVLRE 400 NQMYGTNKMV 410 PYRDSKLTHL 420 FKNYFDGEGK 430 VRMIVCVNPK 440 AEDYEESLQV 450 MRFAEVTQEV 460 EVARPIDRPI 470 CGLTPGRRYR 480 NQARGGPVGD 490 EPLVSEMVLQ 500 SFPPLPPCEI 510 LNINDEQTLP 520 RLIEALEKRH 530 QLRQMMTDEF 540 NKQAITFKAL 550 LQEFDNAVLN 560 KENYIQGKLN 570 EKEKVISGQK 580 LEIERLEKKN 590 KTLEYKIEIL 600 EKTTTIYEED 610 KRSLQQELET 620 QNQKLQRQFS 630 DKRRLEARLQ 640 GMMTETTMKW 650 EKECERRVAA 660 KQLEMQNKLW 670 VKDEKLKQLK 680 AIVTEPRTEK 690 PERPSRERDR 700 EKVTQRSVSP 710 PPVPNAPPIR 720 LRHRRSRSAG 730 DRWVDHKPAS 740 NVQTETVMQP 750 HVPHAITVSV 760 ANEKALAKCE 770 KYMLTHQELA 780 SDGEIETKLI 790 KGDVYKTRGG 800 GQSVQFTDIE 810 TLKQESPTGR 820 KRRSSTAAPA 830 QPDGTESEWT 840 DVETRCSVAV 850 EMRAGSQLGP 860 GYQHHAQPKR KKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0051301 cell division
Biological Process GO:0007018 microtubule-based movement

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.