Search Results
Overview
| Uniprot ID | A0A287BP22 |
|---|---|
| Protein Name | Follistatin-related protein 1 |
| Gene Name | FSTL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | DGHCKEKKSVSPSAS |
| 291 | RYVQELQKHQETAEK |
| 46 | RECAVTEKGEPTCLC |
| 88 | DACLTGSKIQVDYDG |
| 98 | VDYDGHCKEKKSVSP |
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors
Protein Sequence
10
MMWTRWLALA
20
LVAVAWVHAE
30
EEPRSKSKIC
40
ANVFCGAGRE
50
CAVTEKGEPT
60
CLCIEQCKPH
70
KRPVCGSNGK
80
TYLNHCELHR
90
DACLTGSKIQ
100
VDYDGHCKEK
110
KSVSPSASPV
120
VCYQSNRDEL
130
RRRIIQWLEA
140
EIIPDGWFSK
150
GSNYSEILDK
160
YFKNFDNGDS
170
RLDSSEFLKF
180
VEQNETAINI
190
TTYPDQENNK
200
LLRGLCVDAL
210
IELSDENADW
220
KLSFQEFLKC
230
LNPSFNPPEK
240
KCALEDETYA
250
DGAETEVDCN
260
RCVCACGNWV
270
CTAMTCDGKN
280
QKGTQTQTEE
290
EMTRYVQELQ
300
KHQETAEKTK
RVSTKEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0008201 | heparin binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0045446 | endothelial cell differentiation |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030510 | regulation of BMP signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.