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Overview

Uniprot IDA0A287BP76
Protein NameNuclear pore complex protein Nup153
Gene NameNUP153
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1017 SVAPFTCKTPEAKKE
627 QNKVADNKCVACQAT
643 LPPRDTAKQLGTGTP
699 CVACETPKPGTGVKR

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MASGAGGLGG 20 GGGGKIRTRR 30 CHQGPIKPYQ 40 QGRQQHQGIL 50 SRVTESVKNI 60 VPGWLQRYFN 70 KNEDVCSCST 80 DTREVPQWPE 90 NREDDHTMYA 100 DEEGASVHDG 110 RITPEPTVSN 120 TEEPSTTSTA 130 SNYPDVLTRP 140 SLHRSHLNFS 150 MLESPALHCQ 160 PSTSSAFPIG 170 SSGFSLVKEI 180 KDSTSQHDDD 190 NISTTSGFSS 200 RASDKDIAVS 210 KNTSVPPLWS 220 PEAERSHSLS 230 QHTATSSKKP 240 AFNLSAFGTL 250 SPSLGNSSIL 260 KTSQLGDSPF 270 YPGKTMYGGA 280 AAAVRQPKLQ 290 NTPYQAPVRR 300 QMKAKQLNAQ 310 SYGVTSSTAR 320 RILQSLEKMS 330 SPLADAKRIP 340 SVFSSLNSSL 350 DRSGIDNTTD 360 LQAKRRKTGY 370 EKNMSPGQNK 380 ERESGFSYPN 390 FSMSAANGLS 400 SGVGSGGGKM 410 RRERTRFVAS 420 KPQDEEEMEV 430 PVLPKISLPI 440 TSSSLPTFNF 450 SSSVITTSSP 460 SPISPSQSLT 470 NKVQMTSPNS 480 TGSPLFRFSS 490 PIVKSTEADV 500 LPPSSIGFTF 510 SVPVAKTELS 520 GSSTISEPIM 530 SSSAEDITAV 540 NNSTSCKKAD 550 EDGEGLFRPA 560 KTLKEGSVLD 570 VLKNPGFTSP 580 KADSPAAQPT 590 TTSPIVYTRP 600 AISSSSSSGI 610 GFGESLKAGP 620 SWQCDTCLLQ 630 NKVADNKCVA 640 CQATKLPPRD 650 TAKQLGTGTP 660 SKSGKPTLSS 670 PGTGFGDKFK 680 PAVGTWDCDT 690 CLVQNKPEAI 700 KCVACETPKP 710 GTGVKRVFTL 720 PVASESAVTM 730 AASSSSCTVT 740 TGALGFTDKF 750 KRPMGSWECP 760 VCCVSNNAED 770 NKCVSCMSEK 780 PGSSVPASSS 790 STVPVSVLSG 800 GSLGLDKFKK 810 PEGNWNCDVC 820 LVENKADSTK 830 CIACESAKPG 840 TKSEFKGFGT 850 SSSSLNPATS 860 SFKFGIPSSS 870 SAPSQTLTNT 880 GNFKFGDQGG 890 FKIGVSSDLG 900 SVNPMSEEGF 910 KFPKPIGDFK 920 FGVSSDSKPE 930 EVKKDSKNDN 940 NFKFGLSSGL 950 SNPAPLAPFQ 960 FGVSNLGQQE 970 KKEEVPESSS 980 AGFSFCSGVI 990 NPPPLAADTK 1000 VTSESKNSFS 1010 FGTTDTKSVS 1020 VAPFTCKTPE 1030 AKKEETPVTK 1040 GGFTFGSMDS 1050 APLPSASFVL 1060 GRTEEKQQEP 1070 VTSTSLVFGK 1080 KVDTEEPKCQ 1090 PVFSFGNSEQ 1100 TKDEGSSKST 1110 FSFSTAKPSE 1120 KESEQPAKAT 1130 FAFGAQTSTT 1140 ADQGAAKPVF 1150 SFLNNNSSNS 1160 STPATSAGGG 1170 IFGSSTTSSS 1180 APVAAFVFGQ 1190 ASNPVSSSAF 1200 GNSAESSTSQ 1210 SLLFSQESKP 1220 ATTSSTGTAV 1230 TPFVFGPGPS 1240 SNNTATSGFT 1250 FGATTTSSSA 1260 GSSFVFGTGP 1270 SAPSASPAFG 1280 ANQTPTFGQS 1290 QGASQPNPPG 1300 FGSIASSAAL 1310 FSAGSQPAPP 1320 TFGTVSSSSQ 1330 PPVFGQQPSQ 1340 SAFGSGTAPN 1350 SSSVFQFGSS 1360 TTNFNFTNNN 1370 PSGVFTFGAN 1380 PSIPAASAQP 1390 SGSGGFPFNQ 1400 SPGAFTVGSN 1410 GKNIFSSSGT 1420 SLSGRKIKTA VRRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0044615 nuclear pore nuclear basket
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051028 mRNA transport
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.