Search Results

Overview

Uniprot IDA0A287BPH8
Protein NameProtein flightless-1 homolog
Gene NameFLII
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1118 LFRCSNEKGYFAVTE
1167 VEIKLSLKACQVYIQ
503 GEATLDKKACSAIHA
576 VYGKKNIKLEPVPLK
616 ATLSSTTKARLFAEK
777 GTEAQVFKAKFKNWD
952 FTFSLQKKFESLFPG

Function

Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling

Protein Sequence

10 MEATGVLPFV 20 RGVDLSGNDF 30 KGGYFPENVK 40 AMTSLRWLKL 50 NRTGLCYLPE 60 ELAALQKLEH 70 LSVSHNHLTT 80 LHGDLSSLPS 90 LRAIVARANS 100 LKNSGVPDDI 110 FKLDDLSVLD 120 LSYNQLTECP 130 RELENAKNML 140 VLNLSHNRQL 150 PALTALQTLH 160 LRNTQRTQSN 170 LPTSLEGLSN 180 LADVDLSCND 190 LTRVPECLYT 200 LPSLRRLNLS 210 SNQITELSLC 220 IDQWVHVETL 230 NLSRNQLTSL 240 PSAICKLTKL 250 KRLYLNSNKL 260 DFDGLPSGIG 270 KLASLEEFMA 280 ANNNLELIPE 290 SLCRCTKLRK 300 LVLNKNRLVT 310 LPEAVHFLTE 320 IEVLDVRENP 330 SLVMPPKPAD 340 RAAEWYNIDF 350 SLQNQLRLAG 360 ASPATVAAAA 370 AGSGPKDPLA 380 RKMRLRRRKD 390 SAQDDQAKQV 400 LKGMSDVAQE 410 KNRKQEEGAD 420 ARAPGAKVRR 430 WDQGLEKPRL 440 DYSEFFTEDV 450 GQLPGLTIWQ 460 IENFVPVLVE 470 EALHGKFYEA 480 DCYIVLKTFL 490 DDSGSLSWAI 500 YYWIGGEATL 510 DKKACSAIHA 520 VNLRNYLGAE 530 CRTVREEMGD 540 ESEEFLQVFD 550 SDISYVEGGT 560 ASGFYTVEDT 570 HYVTRMYRVY 580 GKKNIKLEPV 590 PLKGASLDPR 600 FVFLLDRGLD 610 IDVWRGAQAT 620 LSSTTKARLF 630 AEKINKNERK 640 GKAEISLLVQ 650 GQEPPEFWEV 660 LGGEPAEIKK 670 HVPDDFWPPQ 680 PKLYKVGLGL 690 GYLELPQINY 700 KLSVEHKTRP 710 KVELMPRMRL 720 LQSLLDTRCV 730 YILDCWSDVF 740 IWLGRKSPRL 750 VRAAALKLGQ 760 ELCGMLHRPR 770 HATVSRSLEG 780 TEAQVFKAKF 790 KNWDDVLTVD 800 YTRNAEAVLQ 810 GPGLAGKVKR 820 DAEKKDQMKA 830 DLTALFLPRQ 840 PPMALAEAEQ 850 LMEEWNEDLD 860 GMEGFVLEGK 870 KFARLPEEEF 880 GHFYTQDCYV 890 FLCRYWVPVE 900 YEEEEERKEE 910 NEDEKAGAEG 920 EDGEAAAAKQ 930 PEEDFQCVVY 940 FWQGREASTM 950 GWLTFTFSLQ 960 KKFESLFPGK 970 LEVVRMTQQQ 980 ENPKFLSHFK 990 RKFVIHRGRR 1000 RAAQGAPQPS 1010 LYQIRTNGSA 1020 LCTRCIQINT 1030 DSGLLNSEFC 1040 FILKVPFESE 1050 DNQGIVYAWV 1060 GRASDPDEAK 1070 LAEDILNSMF 1080 EASYSKQVIN 1090 EGEEPENFFW 1100 VGIGAQKPYD 1110 DDAEYMKHTR 1120 LFRCSNEKGY 1130 FAVTEKCSDF 1140 CQDDLADDDI 1150 MLLDNGQEVY 1160 MWVGTQTSQV 1170 EIKLSLKACQ 1180 VYIQHLRSKE 1190 HERPRRLRLV 1200 RKGNEQHAFT 1210 RCFHAWSTFR KALA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.