Search Results
Overview
| Uniprot ID | A0A287BQ81 |
|---|---|
| Protein Name | Glutathione S-transferase |
| Gene Name | LOC100739163 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | YTNYEAGKEKYVKEL |
| 88 | RSFGLYGKDQKEAAL |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Protein Sequence
10
MGLKTQLGLP
20
PYTITYFPVR
30
GRCEAMRMLL
40
ADQDQSWKEE
50
VVTMETWPPL
60
KPSCLFRQLP
70
KFQDGDLTLY
80
QSNAILRHLG
90
RSFGLYGKDQ
100
KEAALVDMVN
110
DGVEDLRCKY
120
ATLIYTNYEA
130
GKEKYVKELP
140
EHLKPFETLL
150
SQNQGGQAFV
160
VGSQISFADY
170
NLLDLLRIHQ
180
VLNPSCLDAF
190
PLLSAYVARL
200
SARPKIKAFL
210
ASPEHVNRPI
NGNGKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.