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Overview

Uniprot IDA0A287BQK2
Protein NameInter-alpha-trypsin inhibitor heavy chain H3
Gene NameITIH3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
129 DKTAGLVKASGRKLE
227 KKGHVSFKPSLDQQR

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MASARWPCLI 20 LALLSSLAVS 30 GFPRSPSRQL 40 GKRSLPGAVV 50 NGIEVYSTKV 60 SCKVTSRFAH 70 NVVTTRAVNH 80 ADTAKEVSFD 90 VELPKTAFIT 100 NFTLTIDGVT 110 YPGNVKEKEV 120 AKKQYEKAVS 130 QDKTAGLVKA 140 SGRKLEKFTV 150 SVNVAAGSKV 160 TFELTYEELL 170 KRHKGKYEMY 180 LKVQPKQLVK 190 HFEITADIFE 200 PQGISTLDAE 210 ASFITNDLLG 220 SALTKSFSGK 230 KGHVSFKPSL 240 DQQRSCPTCT 250 DSLLKGDFII 260 TYDVNRESPA 270 NVQIVNGYFV 280 HFFAPQGLPV 290 VPKNVVFVID 300 VSGSMYGRKM 310 EQTKDALLKI 320 LDDIKEDDYL 330 NFVLFSGDVT 340 TWKDSLVQAT 350 PENIQKAREF 360 VRNIRDQGMT 370 NINDGLLTGI 380 SMLNKAREEH 390 KVPERSTSII 400 IMLTDGDANM 410 GVSKPEKIQE 420 NVRNAIGGKF 430 PLYNLGFGNN 440 LNYNFLESMA 450 LENHGLARRI 460 YEDSDANLQL 470 QGFYEEVANP 480 LLTSVEVGYP 490 ENAIQDLTQN 500 TYQHFYDGSE 510 IVVAGRLADE 520 DMNSFRADVK 530 GHGAINDLTF 540 TEEVDMKEME 550 EALKERDYIF 560 GNYIERLWAY 570 LTIEQLLEKR 580 KNAQGKEKET 590 LTAQALDLSL 600 KYHFVTPLTS 610 MVVTKPEDNE 620 NQTAIADKPG 630 EVTPSTAYLR 640 VHPTGARRRG 650 EAPGTVRDPR 660 SQPLLCVPSV 670 DGDPHFIIQV 680 PEKDDAICFN 690 IDEDPGTVLR 700 LIQDPVTGLT 710 VNGQIIGEKR 720 SSQDSQPRKT 730 YFGKLGIANA 740 HLDFRIEVTP 750 ERITLWNGAA 760 QSTFSWLDTV 770 MVTQDGLSVM 780 INKKNMVVSF 790 GDGATFVVVL 800 HQVWKKQPNH 810 HDFLGFYVVD 820 SHRMSTQTHG 830 LLGQFFHPFD 840 FKVSDIHPGS 850 DPTKPDATMV 860 VKNHRLTVTR 870 GSQKDYRKDA 880 SIGVKVACWF 890 VHDNGQGLID 900 GIHSDYIVPD LF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.