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Overview

Uniprot ID	A0A287BQR7
Protein Name	Dihydropyrimidinase-related protein 2
Gene Name	DPYSL2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
321	YITKVMSKSAAEVIA
333	VIAQARKKGTVVYGE
535	SGRYIPRKPFPDFVY
583	VTPASSAKTSPAKQQ
588	SAKTSPAKQQAPPVR

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis

Protein Sequence

10 MAPTTLRSLR 20 HPFSVLSAAP 30 YLPAECPEST 40 SFCPFSYPLA 50 RTRGRRAGGE 60 PSVESGRKVE 70 IRRASGKEAL 80 QNINDQSDRL 90 LIKGGKIVND 100 DQSFYADIYM 110 EDGLIKQIGE 120 NLIVPGGVKT 130 IEAHSRMVIP 140 GGIDVHTRFQ 150 MPDQGMTSAD 160 DFFQGTKAAL 170 AGGTTMIIDH 180 VVPEPGTSLL 190 SAFDQWREWA 200 DSKSCCDYSL 210 HVDITEWHKG 220 IQEEMEALVK 230 DHGVNSFLVY 240 MAFKDRFQLT 250 DSQIYEVLSV 260 IRDIGAIAQV 270 HAENGDIIAE 280 EQQRILDLGI 290 TGPEGHVLSR 300 PEEVEAEAVN 310 RSITIANQTN 320 CPLYITKVMS 330 KSAAEVIAQA 340 RKKGTVVYGE 350 PITASLGTDG 360 SHYWSKNWAK 370 AAAFVTSPPL 380 SPDPTTPDFL 390 NSLLSCGDLQ 400 VTGSAHCTFN 410 TAQKAVGKDN 420 FTLIPEGTNG 430 TEERMSIIWD 440 KAVVTGKMDE 450 NQFVAVTSTN 460 AAKVFNLYPR 470 KGRIAVGSDA 480 DLVIWDPDSV 490 KTISAKTHNS 500 SLEYNIFEGM 510 ECRGSPLVVI 520 SQGKIVLEDG 530 TLHVTEGSGR 540 YIPRKPFPDF 550 VYKRIKARSR 560 LAELRGVPRG 570 LYDGPVCEVS 580 VTPKTVTPAS 590 SAKTSPAKQQ 600 APPVRNLHQS 610 GFSLSGAQID 620 DNIPRRTTQR 630 IVAPPGGRAN ITSLG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0120025	plasma membrane bounded cell projection
Molecular Function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007399	nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.