Search Results

Overview

Uniprot IDA0A287BQT2
Protein NameCytoplasmic aconitate hydratase
Gene NameACO1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
387 VAVSDMKKDFESCLG
396 FESCLGAKQGFKGFQ

Function

Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA

Protein Sequence

10 MSNPFAHLAE 20 PLDPAQPGKK 30 FFNLNKLEDS 40 RYGRLPFSIR 50 VLLEAAIRNC 60 DQFLVKKDDV 70 ENILNWNVLQ 80 HENIEVPFKP 90 ARVILQDFTG 100 VPAVVDFAAM 110 RDAVKKLGGN 120 PEKINPVCPA 130 DLVIDHSIQV 140 DFNRRADSLQ 150 KNQDLEFERN 160 RERFEFLKWG 170 SQAFRNMRII 180 PPGSGIIHQV 190 NLEYLARVVF 200 DQDGYYYPDS 210 LVGTDSHTTM 220 IDGLGILGWG 230 VGGIEAEAVM 240 LGQPISMVLP 250 QVIGYKLMGN 260 PHPLVTSTDI 270 VLTITKHLRQ 280 VGVVGKFVEF 290 FGPGVAQLSI 300 ADRATIANMC 310 PEYGATAAFF 320 PVDEVSIKYL 330 VQTGRDEDKV 340 KHIKKYLQAV 350 GMFRDFSDSS 360 QDPDFAQVVE 370 LDLKTVVPCC 380 SGPKRPQDKV 390 AVSDMKKDFE 400 SCLGAKQGFK 410 GFQIAPDHHN 420 DHKTFIYDNS 430 EFTLAHGSVV 440 IAAITSCTNT 450 SNPSVMLGAG 460 LLAKKAVDAG 470 LNVKPYIKTS 480 LSPGSGVVTY 490 YLRESGVMPY 500 LSQLGFDVVG 510 YGCMTCIGNS 520 GPLPEAVVEA 530 ITQGDLVAVG 540 VLSGNRNFEG 550 RVHPNTRANY 560 LASPPLVIAY 570 AIAGTIRIDF 580 EKEPLGMNAK 590 GQQVFLKDIW 600 PTRDEIQAVE 610 RQFVIPGMFK 620 EVYQKIETVN 630 ESWNALEAPS 640 DTLYSWNPKS 650 TYIKSPPFFE 660 DLTLDLQPPK 670 SIVDAYVLLN 680 LGDSVTTDHI 690 SPAGNIARNS 700 PAARYLTNRG 710 LTPRDFNSYG 720 SRRGNDAIMA 730 RGTFANIRLL 740 NKFLNKQAPQ 750 TIHLPSGEVL 760 DVFDAAERYQ 770 QAGLPLIILA 780 GKEYGSGSSR 790 DWAAKGPFLL 800 GIKAVLAESY 810 ERIHRSNLVG 820 MGVIPLEYLP 830 GENADTLGLT 840 GRERYTISIP 850 ETLKPQMKVQ 860 VKLDTGKTFQ 870 AVMRFDTDVE 880 LTYFHNGGIL NYMIRKMAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0051538 3 iron, 4 sulfur cluster binding
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0003994 aconitate hydratase activity
Molecular Function GO:0030350 iron-responsive element binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0010040 response to iron(II) ion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.