Search Results
Overview
| Uniprot ID | A0A287BR55 |
|---|---|
| Protein Name | Cell cycle checkpoint protein RAD17 |
| Gene Name | RAD17 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 395 | KSDAALSKSKRRQKP |
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression
Protein Sequence
10
MLLPEGELYF
20
NVLQVVYSGW
30
ELSKFIMSKT
40
FLRPKVSSTK
50
VTDWVDPSFD
60
DFSETTNIST
70
INATSLSVNN
80
SSLRRKKVPS
90
TLESRRSPTR
100
KRGNLSSSKQ
110
IYSLENSKEY
120
VSENEPWVDK
130
YKPETQHELA
140
VHKKKIEEVE
150
TWLKVEVLER
160
QPTQGGSILL
170
ITGPPGCGKT
180
ATIKILSKEH
190
GIQVQEWINP
200
VLPEFQKDDF
210
KEIFNPESSF
220
HIFPYQSQIA
230
VFKEFLLRAT
240
KYNKLQMLGD
250
DLTTDKKIIL
260
VEDLPNQFYR
270
DPHILHEVLR
280
RYVQVGRCPL
290
IFIISDSLSG
300
DNNHRLLFPK
310
EIQEECAISN
320
ISFNPVAPTI
330
MMKFLNRIVT
340
KEANKNGGKI
350
IVPDKTSLEL
360
LCQGCSGDIR
370
SAINSLQFSS
380
STGKNNLWPR
390
KKGTSSLKSD
400
AALSKSKRRQ
410
KPDRVFENQE
420
VQAIGGKDVS
430
LFLFRALGKI
440
LYCKRASVTE
450
LDSPRLPSHL
460
SEYERDTLLI
470
HPEEVVEMSH
480
MPGDLFNLYL
490
HQNYVDFFMD
500
VDDLVRASEF
510
LSFADILSGD
520
WNTRSLLREY
530
STSVATRGVI
540
HSNRARGFAN
550
CQGGGSSFRP
560
LHKPQWFLIN
570
KKYRENCLAA
580
KALFSDFCLS
590
PVCLQTQLLP
600
YLALLTIPMR
610
NQAQISFIQD
620
IGRLPLKRHF
630
GRLKMEALTD
640
REHGMMDLDS
650
GDEAQLGGGQ
660
PTEEALGEPT
670
PSTEPEPELL
680
SLPLSQNSGS
690
ELPASQPRPF
700
SAQGDMEEED
710
MIIEDYESDG
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0140445 | chromosome, telomeric repeat region |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031389 | Rad17 RFC-like complex |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140463 | chromatin-protein adaptor activity |
| Molecular Function | GO:0003689 | DNA clamp loader activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0033314 | mitotic DNA replication checkpoint signaling |
| Biological Process | GO:0031573 | mitotic intra-S DNA damage checkpoint signaling |
| Biological Process | GO:0008156 | negative regulation of DNA replication |
| Biological Process | GO:1990166 | protein localization to site of double-strand break |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.