Overview
| Uniprot ID | A0A287BRS7 |
|---|
| Protein Name | Integrator complex subunit 9 |
|---|
| Gene Name | INTS9 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 559 |
PAQPVGGKKRKRASE |
Function
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex
Protein Sequence
10
MKLYCLSGHP
20
TLPCNVLKFK
30
STTIMLDCGL
40
DMTSTLNFLP
50
LPLVQSPRLS
60
NLPGWSLKDG
70
NAFLDKELKE
80
CSGHVFVDSV
90
PEFCLPETEL
100
IDLSTVDVIL
110
ISNYHCMMAL
120
PYITEHTGFT
130
GTVYATEPTV
140
QIGRLLMEEL
150
VNFIERVPKA
160
QSASLWKNKD
170
IQRLLPSPLK
180
DAVEVSTWRR
190
CYTMQEVNSA
200
LSKIQMELFG
210
AVQVTPLSSG
220
YALGSSNWII
230
QSHYEKVSYV
240
SGSSLLTTHP
250
QPMDQASLKN
260
SDVLILTGLT
270
QIPTANPDGM
280
VGEFCSNLAL
290
TVRNGGNVLV
300
PCYPSGVIYD
310
LLECLYQYID
320
SAGLSSIPFY
330
FISPVANSSL
340
EFSQIFAEWL
350
CHNKQTKVYL
360
PEPPFPHAEL
370
IQTNKLKHYP
380
SIHGDFSNDF
390
RQPCVVFTGH
400
PSLRFGDVVH
410
FMELWGKSSL
420
NTVIFTEPDF
430
SYLEALAPYQ
440
PLAMKCIYCP
450
IDTRLNFIQV
460
SKLLKEVQPL
470
HVVCPEQYTQ
480
PPPAQSHRMD
490
LMIDCQPPAM
500
SYRRAEVLAL
510
PFKRRYEKIE
520
IMPELADSLV
530
PMEIKPGISL
540
ATVSAVLHTK
550
DNKHVLQPPP
560
RPAQPVGGKK
570
RKRASEEVPD
580
CKVVKPLLSG
590
SIPVEQFVQT
600
LEKHGFSDIK
610
VEDTAKGHIV
620
LLQEAETLIQ
630
IEEDSTHIIC
640
DNDEMLRVRL
650
RDLVLKFLQK
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0160232 |
INTAC complex |
| Cellular Component |
GO:0032039 |
integrator complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0034243 |
regulation of transcription elongation by RNA polymerase II |
| Biological Process |
GO:0160240 |
RNA polymerase II transcription initiation surveillance |
| Biological Process |
GO:0034472 |
snRNA 3'-end processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.