Search Results
Overview
| Uniprot ID | A0A287BRY9 |
|---|---|
| Protein Name | Midkine |
| Gene Name | MDK |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | RVPCNWKKEFGADCK |
| 129 | FGADCKYKFESWGAC |
Function
Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration
Protein Sequence
10
MEQGLDGVKC
20
CTRASGAGAA
30
HRLPAGPAPR
40
PVTHPGLRAP
50
SRMQRRGFLL
60
LALFALLALT
70
DAVAKKKDKV
80
KKGGPGSECA
90
EWTWGPCTPS
100
SKDCGVGFRE
110
GTCGAQTQRV
120
RCRVPCNWKK
130
EFGADCKYKF
140
ESWGACDGGT
150
GTKARQGTLK
160
KARYNAQCQE
170
TIRVTKPCTP
180
KTKAKAKAKK
GKGKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0035374 | chondroitin sulfate binding |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:1904399 | heparan sulfate binding |
| Molecular Function | GO:0008201 | heparin binding |
| Biological Process | GO:0001662 | behavioral fear response |
| Biological Process | GO:0021681 | cerebellar granular layer development |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0030421 | defecation |
| Biological Process | GO:0021542 | dentate gyrus development |
| Biological Process | GO:0044849 | estrous cycle |
| Biological Process | GO:0106091 | glial cell projection elongation |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0002232 | leukocyte chemotaxis involved in inflammatory response |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| Biological Process | GO:1904036 | negative regulation of epithelial cell apoptotic process |
| Biological Process | GO:0106015 | negative regulation of inflammatory response to wounding |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0030279 | negative regulation of ossification |
| Biological Process | GO:0045590 | negative regulation of regulatory T cell differentiation |
| Biological Process | GO:0048477 | oogenesis |
| Biological Process | GO:1905653 | positive regulation of artery morphogenesis |
| Biological Process | GO:1905555 | positive regulation of blood vessel branching |
| Biological Process | GO:0061036 | positive regulation of cartilage development |
| Biological Process | GO:0051781 | positive regulation of cell division |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:2000347 | positive regulation of hepatocyte proliferation |
| Biological Process | GO:0106016 | positive regulation of inflammatory response to wounding |
| Biological Process | GO:0032735 | positive regulation of interleukin-12 production |
| Biological Process | GO:0010838 | positive regulation of keratinocyte proliferation |
| Biological Process | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell |
| Biological Process | GO:0010759 | positive regulation of macrophage chemotaxis |
| Biological Process | GO:2000179 | positive regulation of neural precursor cell proliferation |
| Biological Process | GO:2001224 | positive regulation of neuron migration |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0090023 | positive regulation of neutrophil chemotaxis |
| Biological Process | GO:2000391 | positive regulation of neutrophil extravasation |
| Biological Process | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| Biological Process | GO:0071673 | positive regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0045582 | positive regulation of T cell differentiation |
| Biological Process | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| Biological Process | GO:0050795 | regulation of behavior |
| Biological Process | GO:0046850 | regulation of bone remodeling |
| Biological Process | GO:0032330 | regulation of chondrocyte differentiation |
| Biological Process | GO:0010996 | response to auditory stimulus |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0007614 | short-term memory |
| Biological Process | GO:0002286 | T cell activation involved in immune response |
| Biological Process | GO:0042246 | tissue regeneration |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.