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Overview

Uniprot IDA0A287BSS7
Protein NameC-Jun-amino-terminal kinase-interacting protein 4
Gene NameSPAG9
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1057 VWCGYRNKIYVVQPK
593 LSQLPGDKSKAFDFL
990 CLHSIKLKDSILSIV

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking

Protein Sequence

10 MELEDGVVYQ 20 EEPGGSGAVM 30 SERVSGLAGS 40 IYREFERLIG 50 RYDEEVVKEL 60 MPLVVAVLEN 70 LDSVFAQDQE 80 HQVELELLRD 90 DNEQLITQYE 100 REKALRKHAE 110 EKFIEFEDSQ 120 EQEKKDLQTR 130 VESLESQTRQ 140 LELKAKNYAD 150 QISRLEEREA 160 ELKKEYNALH 170 QRHTEMIHNY 180 MEHLERTKLH 190 QLSGSDQLES 200 TAHSRIRKER 210 PISLGIFPLP 220 AGEGLLTPDT 230 QKGGETPGSE 240 QWKFQELSQP 250 RSHTSLKDEL 260 SDVSQGGSKA 270 TTPASTAASD 280 VAAIPADTPL 290 NEDNEGFVKV 300 AETPDKSEIS 310 KHIEVQVAQE 320 TRNVSIGSAE 330 NEEKSEVQAI 340 IESTPELDMD 350 KDLSGYKGSS 360 TPTKGIENKA 370 FDRNTESLFE 380 ELSSAGSGLI 390 GDVDEGADLL 400 GMGREVENLI 410 LENTQLLETK 420 NALNVVKNDL 430 IAKVDELTCE 440 KDVLQGELEA 450 VKQAKLKLEE 460 KNKELEEELR 470 KARAEAEDAR 480 QKAKDDDDSD 490 IPTAQRKRFT 500 RVEMARVLME 510 RNQYKERLME 520 LQEAVRWTEM 530 IRASRENPAM 540 QEKKRSSIWQ 550 FMPARFSRLF 560 SSSSNTTKKP 570 EPPVNLKYNA 580 PTSHVTPSVK 590 KRSSTLSQLP 600 GDKSKAFDFL 610 SEETEASLAS 620 RREQKREQYR 630 QVKAHVQKED 640 GRVQAFGWSL 650 PQKYKQVTNG 660 QGENKMKNLP 670 VPVYLRPLDE 680 KDASMKLWCA 690 VGVNLSGGKT 700 RDGGSVVGAS 710 VFYKDVAGLE 720 SEGSKQRSAS 730 QSSLDKLDQE 740 LKEQQKELKN 750 QEELSSLVWI 760 CTSTHSATKV 770 IIIDAVQPGN 780 ILDSFTVCNS 790 HVLCIASVPG 800 ARETDYPAGE 810 ELSESGQVDK 820 ASLCGSMTSN 830 SSTETDSLLG 840 GITVVGCSTE 850 GVTAVATSPS 860 TNGTSPVTEK 870 PPEKEAENSE 880 VDENVPTAEE 890 ATEATEGNAG 900 SAEDTVDISQ 910 AGVYTEHVFT 920 DPLGVQIPED 930 LSPVYQSSND 940 SDAYKDQISV 950 LPNEQDLVRE 960 EAQKMSSLLP 970 TMWLGAQNGC 980 LYVHSSVAQW 990 RKCLHSIKLK 1000 DSILSIVHVK 1010 GIVLVALADG 1020 TLAIFHRGVD 1030 GQWDLSNYHL 1040 LDLGRPHHSI 1050 RCMTVVHDKV 1060 WCGYRNKIYV 1070 VQPKAMKIEK 1080 SFDAHPRKES 1090 QVRQLAWVGD 1100 GVWVSIRLDS 1110 TLRLYHAHTY 1120 QHLQDVDIEP 1130 YVSKMLGTGK 1140 LGFSFVRITA 1150 LMVSCNRLWV 1160 GTGNGVIISI 1170 PLTETNKTSG 1180 ASGNRPGSVI 1190 RVYGDENSDK 1200 VTPGTFIPYC 1210 SMAHAQLCFH 1220 GHRDAVKFFV 1230 AVPGQVISPQ 1240 SGSSGTDLTA 1250 DKVGPSAQEP 1260 GSQTPLKSML 1270 VISGGEGYID 1280 FRMGDEGGES 1290 ELLGEDLPLE 1300 PSVTKAERSH 1310 LIVWQVMYGS E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005078 MAP-kinase scaffold activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.