Overview
| Uniprot ID | A0A287BT03 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 2A activator |
|---|
| Gene Name | PTPA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
NEGVKGKKLTFEYRV |
| 351 |
YKAECLEKFPVIQHF |
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A
Protein Sequence
10
EPSKLLEPAS
20
ARFSSESSER
30
VGEPGKGREG
40
AGVKGERGLQ
50
ASGPAPGGRK
60
MAEGERQSPP
70
DSLEDTPPAT
80
QNFIIPKKEI
90
HTVPDMGKWK
100
RSQAYADYMG
110
FILTLNEGVK
120
GKKLTFEYRV
130
SEAIEKLVTL
140
LNTLDRWIDE
150
TPPVDQPSRF
160
GNKAYRTWYA
170
KLDQEAENLV
180
ATVVPTHLAA
190
AVPEVSVYLK
200
ESVGNSTRID
210
YGTGHEAAFA
220
AFLCCLCKIG
230
VLRVDDQIAI
240
VFKVFSRYLE
250
VMRKLQKTYR
260
MEPAGSQGVW
270
GLDDFQFLPF
280
IWGSSQLIDH
290
PHLEPRHFVD
300
EKAVNENHED
310
YMFLECILFI
320
TMKTGPFAEH
330
SNQLWNISAV
340
PSWSKVNQGL
350
IRMYKAECLE
360
KFPVIQHFKF
370
GSLLPIHPVA
SC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000159 |
protein phosphatase type 2A complex |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function |
GO:0008160 |
protein tyrosine phosphatase activator activity |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.