Search Results

Overview

Uniprot IDA0A287BT76
Protein NameElongation factor-like GTPase 1
Gene NameEFL1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
204 FAKIYSQKTGIRKEV
401 ARRRHAEKLAAAQGQ
462 GVARRGKKIFVLGPK
954 RVYAVLSKREGRVLQ

Function

GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export

Protein Sequence

10 MVLNSLDKMI 20 QLQKNTANIR 30 NICVLAHVDH 40 DDEEYLINLI 50 DSPGHVDFSS 60 EVSTAVRICD 70 GCIIVVDAVE 80 GVCPQTQAVL 90 RQAWLENIRP 100 VLVINKIDRL 110 IVELKFTPQE 120 AYSHLKNILE 130 QINALTGTLF 140 TSKVLEERAE 150 RVTESQVNPH 160 SEQGEQVYDW 170 STGLEDTDDS 180 HLYFSPDQGN 190 VVFTSAIDGW 200 GFGIEHFAKI 210 YSQKTGIRKE 220 VLLKTLWGDY 230 YINMKAKKIM 240 KVDQAKGKKP 250 LFVQLILGNI 260 WSLYDAVLKK 270 DKEKIDKIVT 280 SLGLKIGARE 290 ARHSDPKVQI 300 NAICSQWLPI 310 SQAVLAMVCQ 320 KLPSPLDITA 330 ERVEKLMCAG 340 SQTFDSLPPE 350 TQALKAAFMK 360 CGSEDTAPVI 370 IFVSKMFAVD 380 AKALPQNKPR 390 PLTPEEIAER 400 RERARRRHAE 410 KLAAAQGQAP 420 VEPTQDGSAL 430 EASPKEEEPK 440 GDEQQVLQEG 450 NDQESFIAFA 460 RVFSGVARRG 470 KKIFVLGPKY 480 SPLEFLQRVP 490 LGFSAPLDGL 500 PPVPHMACCT 510 LENLYLLMGR 520 ELEDLEEVPP 530 GNVLGIGGLQ 540 DFVLKSATLC 550 TLPSCPPFIP 560 LNFEATPIVR 570 VAVEPKHPSE 580 MPQLVKGMKL 590 LNQADPCVQI 600 LIQETGEHVL 610 VTAGEVHLQR 620 CLDDLKERFA 630 KIQISVSEPI 640 IPFRETITKP 650 PKVDMVNEEI 660 GKQQKVAVIH 670 QTKEDQSKIP 680 EGIQVDSDGL 690 VTITTPNKLA 700 TLCVRAMPLP 710 EEVTQILEEN 720 SDLIRSMEQL 730 TSSLNEGKNT 740 QVIHQKTQEK 750 IGEFKGRLEQ 760 HLTGRKWRNT 770 VDQIWSFGPR 780 KCGPNILVNK 790 SEDFQNSVWT 800 GPDGKASQEA 810 NRYRDLGNSI 820 VSGFQLATLS 830 GPMCEEPLMG 840 VCFVLEKWDL 850 SKFEEQTASD 860 KQNQKQSDLV 870 DAGQGEGETS 880 SAGDENQEVH 890 NGCSEPFEKR 900 PSQKGESSLT 910 DCYGPFSGQL 920 IATMKEACRY 930 ALQVKPQRLM 940 AAMYTCDIMA 950 TSDVLGRVYA 960 VLSKREGRVL 970 QEEMKEGTDM 980 FIIKAVLPVA 990 ESFGFADEIR 1000 KRTSGLASPQ 1010 LVFSHWEIIP 1020 SDPFWVPTTE 1030 EEYLHFGEKA 1040 DSENQARKYM 1050 NAVRKRKGLY 1060 VEEKIVEHAE KQRTLSKNK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0042256 cytosolic ribosome assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.