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Overview

Uniprot IDA0A287BTK2
Protein NameCalcium-transporting ATPase
Gene NameATP2B1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
247 TGESDHVKKSLDKDP
587 GSYRIFSKGASEIIL
64 YGICTRLKTSPVEGL
743 IEQERIDKIWPKLRV
759 ARSSPTDKHTLVKGI

Function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles

Protein Sequence

10 MGDMANNSVA 20 YGGVKNSLKE 30 ANHDGDFGIT 40 LAELRALMEL 50 RSTDALRKIQ 60 ESYGDVYGIC 70 TRLKTSPVEG 80 LSGNPADIER 90 REAVFGKNFI 100 PPKKPKTFLQ 110 LVWEALQDVT 120 LIILEIAAIV 130 SLGLSFYQPP 140 EGDNALSVGE 150 EEGEGETGWI 160 EGAAILLSVV 170 CVVLVTAFND 180 WSKEKQFRGL 190 QSRIEQEQKF 200 TVIRGGQVIQ 210 IPVADITVGD 220 IAQVKYGDLL 230 PADGILIQGN 240 DLKIDESSLT 250 GESDHVKKSL 260 DKDPLLLSGT 270 HVMEGSGRMV 280 VTAVGINSQT 290 GIIFTLLGAG 300 GEEEEKKDEK 310 KKEKKSKNTK 320 AQDGAAMEMQ 330 PLKSEEGGDG 340 DEKDKKKANL 350 PKKEKSVLQG 360 KLTKLAVQIG 370 KAGLLMSAIT 380 VIILVLYFVI 390 DTFWVQKRPW 400 LAECTPIYIQ 410 YFVKFFIIGV 420 TVLVVAVPEG 430 LPLAVTISLA 440 YSVKKMMKDN 450 NLVRHLDACE 460 TMGNATAICS 470 DKTGTLTMNR 480 MTVVQAYINE 490 KHYKKIPEPE 500 AIPPNILSYL 510 VTGISVNCAY 520 TSKILPPEKE 530 GGLPRHVGNK 540 TECALLGLLL 550 DLKRDYQDVR 560 NEIPEEALYK 570 VYTFNSVRKS 580 MSTVLKNSDG 590 SYRIFSKGAS 600 EIILKKCFKI 610 LSANGEAKVF 620 RPRDRDDIVK 630 TVIEPMASEG 640 LRTICLAFRD 650 FPAGEPEPEW 660 DNENDIVTGL 670 TCIAVVGIED 680 PVRPEVPDAI 690 KKCQRAGITV 700 RMVTGDNINT 710 ARAIATKCGI 720 LHPGEDFLCL 730 EGKDFNRRIR 740 NEKGEIEQER 750 IDKIWPKLRV 760 LARSSPTDKH 770 TLVKGIIDST 780 VSDQRQVVAV 790 TGDGTNDGPA 800 LKKADVGFAM 810 GIAGTDVAKE 820 ASDIILTDDN 830 FTSIVKAVMW 840 GRNVYDSISK 850 FLQFQLTVNV 860 VAVIVAFTGA 870 CITQDSPLKA 880 VQMLWVNLIM 890 DTLASLALAT 900 EPPTESLLLR 910 KPYGRNKPLI 920 SRTMMKNILG 930 HAFYQLVVVF 940 TLLFAGEKFF 950 DIDSGRNAPL 960 HAPPSEHYTI 970 VFNTFVLMQL 980 FNEINARKIH 990 GERNVFEGIF 1000 NNAIFCTIVL 1010 GTFVVQIIIV 1020 QFGGKPFSCS 1030 ELSIEQWLWS 1040 IFLGMGTLLW 1050 GQLISTIPTS 1060 RLKFLKEAGH 1070 GTQKEEIPEE 1080 ELAEDVEEID 1090 HAERELRRGQ 1100 ILWFRGLNRI 1110 QTQIRVVNAF 1120 RSSLYEGLEK 1130 PESRSSIHNF 1140 MTHPEFRIED 1150 SEPHIPLIDD 1160 TDAEDDAPTK 1170 RNCSPPPSPN 1180 KNNNAVDSGI 1190 YLTIEMNKSA 1200 TSSSPGSPLH SLETSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005388 P-type calcium transporter activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.