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Overview

Uniprot ID	A0A287BTM5
Protein Name	DNA mismatch repair protein MSH2
Gene Name	MSH2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
528	YYFRVTCKEEKVLRN
537	EKVLRNNKNFSTVDI

Function

Component of the post-replicative DNA mismatch repair system (MMR)

Protein Sequence

10 MAVQPKETLQ 20 LESAAEIGFV 30 RFFQGMPEKP 40 TTTVRLFDRG 50 DFYTAHGEDA 60 LLAAREVFKT 70 QGVVKFMGPA 80 GAKTLESVVL 90 SKMNFESFVK 100 DLLLVRQYRV 110 EVYKNRAGNK 120 ASKEHDWYLA 130 FKASPGNLSQ 140 FEDILFGNND 150 MSASIGVVGV 160 KMSTVDGQRQ 170 VGVGYVDSIQ 180 RKLGLCEFPD 190 NDQFSNLEAL 200 LIQIGPKECV 210 LPGGDTAGDM 220 GKLRQVIQRG 230 GILITERKRA 240 DFSTKDIYQD 250 LNRLLKGKKG 260 EQMNSAVLPE 270 MENQVAVSSL 280 SAVIKFLELL 290 ADDSNFGQFE 300 LTTFDFSQYM 310 KLDMAAVRAL 320 NLFQGSVEDT 330 AGSQSLAALL 340 NKCKTPQGQR 350 LVNQWIKQPL 360 MDKNRIEERL 370 NLVEAFVEDA 380 ELRQSLQEDL 390 LRRFPDLNRL 400 AKKFQRQAAN 410 LQDCYRLYQG 420 INQLPNVIQA 430 MEKYEGQHQA 440 LLLAVFVTPL 450 IDLRSDFSKF 460 QEMIETTLDM 470 DQVENHEFLV 480 KPSFDPNLSE 490 LREIMDDLEK 500 KMQSTLISAA 510 RDLGLDPGKQ 520 IKLDSSAQFG 530 YYFRVTCKEE 540 KVLRNNKNFS 550 TVDIQKNGVK 560 FTNSKLTSLN 570 EEYTKNKTEY 580 EEAQNAIVKE 590 IVNISSGYVE 600 PMQTLNDVLA 610 QLDAVVSFAH 620 VSNGAPVPYV 630 RPVILEKGQG 640 RITLKASRHA 650 CVEVQDEVAF 660 IPNDVHFEKD 670 KQMFHIITGP 680 NMGGKSTYIR 690 QTGVVVLMAQ 700 IGCFVPCESA 710 EVSIVDCILA 720 RVGAGDSQLK 730 GVSTFMAEML 740 ETASILRSAT 750 KDSLIIIDEL 760 GRGTSTYDGF 770 GLAWAISEYI 780 ATKIGAFCMF 790 ATHFHELTAL 800 ANQIPTVNNL 810 HVTALTTEET 820 LTMLYQVKKG ECVPLV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity
Molecular Function	GO:0030983	mismatched DNA binding
Biological Process	GO:0006298	mismatch repair

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.