Search Results
Overview
| Uniprot ID | A0A288CFT0 |
|---|---|
| Protein Name | Triosephosphate isomerase |
| Gene Name | TPI1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | REAGITEKVVFEQTK |
| 186 | KVVFEQTKVIADNVK |
| 193 | KVIADNVKDWNKVVL |
| 225 | QAQEVHEKLRGWLKT |
| 231 | EKLRGWLKTHVSEAV |
| 43 | SAMAPARKFFVGGNW |
| 56 | NWKMNGRKNNLGELI |
| 96 | ARQKLDPKIAVAAQN |
Function
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids
Protein Sequence
10
MAQDAKGAGF
20
CLSALYISGQ
30
WRRPRAAPDL
40
QCAGSSAMAP
50
ARKFFVGGNW
60
KMNGRKNNLG
70
ELINTLNAAK
80
LPADTEVVCA
90
PPTAYIDFAR
100
QKLDPKIAVA
110
AQNCYKVANG
120
AFTGEISPGM
130
IKDLGATWVV
140
LGHSERRHVF
150
GESDELIGQK
160
VAHALAEGLG
170
VIACIGEKLD
180
EREAGITEKV
190
VFEQTKVIAD
200
NVKDWNKVVL
210
AYEPVWAIGT
220
GKTATPQQAQ
230
EVHEKLRGWL
240
KTHVSEAVAQ
250
STRIIYGGSV
260
TGATCKELAS
270
QPDVDGFLVG
280
GASLKPEFVD
IINAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008929 | methylglyoxal synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004807 | triose-phosphate isomerase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process | GO:0019563 | glycerol catabolic process |
| Biological Process | GO:0006096 | glycolytic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.