Search Results

Overview

Uniprot ID	A0A288CFT7
Protein Name	Calpastatin
Gene Name	CAST
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
156	HSADAGSKRAHKEKA
192	DPTPSDGKLSVTGVS
224	SSVPAESKSSKPSGK
227	PAESKSSKPSGKSDM
30	TQEHVSGKTSGSSSK
336	GKKTEKEKSTGEVLK
476	SKPTEKTKESQATAP
48	QKGSDEKKAASLGSS
526	LAGSLGKKEADPEDG
579	DGKTLPHKDPKEPVL

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MSQPGQKPAA 20 SPRPRRAAAA 30 RHTQEHVSGK 40 TSGSSSKSGE 50 QKGSDEKKAA 60 SLGSSQPSRI 70 QAGGTAPVTK 80 ECKHPQTPLK 90 SLCREARSRV 100 SPSSASTSKS 110 SSMNPTETKA 120 VKTEPEKKSQ 130 STKPSVVHEK 140 KTQEVKPKEH 150 PEPKSLPTHS 160 ADAGSKRAHK 170 EKAVSRSNEQ 180 PTSEKSTKPK 190 AKPQDPTPSD 200 GKLSVTGVSA 210 ASGKPAETKK 220 DDKSLTSSVP 230 AESKSSKPSG 240 KSDMDAALDD 250 LIDTLGGPEE 260 TEEDNTTYTG 270 PEVLDPMSST 280 YIEELGKREV 290 TLPPKYRELL 300 DKKEGIPVPP 310 PDTSKPLGPD 320 DAIDALSLDL 330 TCSSPTADGK 340 KTEKEKSTGE 350 VLKAQSVGVI 360 KSAAAPPHEK 370 KRRVEEDTMS 380 DQALEALSAS 390 LGSRKSEPEL 400 DLSSIKEIDE 410 AKAKEEKLKK 420 CGEDDETVPP 430 EYRLKPAMDK 440 DGKPLLPEAE 450 EKPKPLSESE 460 LIDELSEDFD 470 QSKRKEKQSK 480 PTEKTKESQA 490 TAPTPVGEAV 500 SRTSLCCVQS 510 APPKPATKGM 520 VPDDAVEALA 530 GSLGKKEADP 540 EDGKPVEDKV 550 KEKAKEEDRE 560 KLGEKEETIP 570 PDYRLEEVKD 580 KDGKTLPHKD 590 PKEPVLPLSE 600 DFVLDALSQD 610 FAGPPAASSL 620 QFEDAKLSAA 630 VSEVVSQTSA 640 PTTHSAGPPP 650 DTVQSDDKKL 660 DDALDQLSDS 670 LGQRQPDPDE 680 NKPIEDKVKE 690 KAEAEHRDKL 700 GERDDTIPPE 710 YRHLLDKDEE 720 GKSTKPPTKK 730 PEAPKKPEAA 740 QDPIDALSGD 750 FDRCPSTTET 760 SENTTKDKDK 770 KTASKSKAPK 780 NGGKAKDSTK 790 AKEETSKQKS DGKSTS

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.