Overview
| Uniprot ID | A0A288CFU5 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 3 |
|---|
| Gene Name | PTBP3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 428 |
SGQRLYGKVLRATLS |
| 508 |
TEAGCSVKAFKFFQK |
| 511 |
GCSVKAFKFFQKDRK |
| 52 |
GNDNKKFKGDRPPCS |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MDGVVTDLIA
20
VGLKRGSDEL
30
LSSGIINGPF
40
TMNSSTPSTG
50
VFANGNDNKK
60
FKGDRPPCSP
70
SRVLHLRKIP
80
SDVTEAEVIS
90
LGLPFGKVTN
100
LLMLKGKSQA
110
FLEMASEEAA
120
VTMVNYYTPV
130
TPHLRSQPVF
140
IQYSNHRELK
150
TDNLPNQARA
160
QAALQAVSAV
170
QSGSLGLPGA
180
PTNEGTILPG
190
QSPVLRIIIE
200
NLFYPVTLEV
210
LHQIFSKFGT
220
VLKIITFTKN
230
NQFQALLQYA
240
DPLNAHYAKM
250
ALDGQNIYNA
260
CCTLRIDFSK
270
LTSLNVKYNN
280
DKSRDFTRLD
290
LPTGDGQPSL
300
EPPMAAAFGA
310
PGIISSPYAG
320
AAGFAPAIGF
330
PQATGLSVPA
340
GLGPGALGPL
350
AITSSAVTGR
360
MAMPGTGGIP
370
GNSVLLVTNL
380
NPDLVTPHGL
390
FILFGVYGDV
400
HRVKIMFNKK
410
ENALVQMADA
420
NQAQLAMNHL
430
SGQRLYGKVL
440
RATLSKHQAV
450
QLPREGQEDQ
460
GLTKDFSNSP
470
LHRFKKPGSK
480
NFQNIFPPSA
490
TLHLSNIPPS
500
VTVDDLKNLF
510
TEAGCSVKAF
520
KFFQKDRKMA
530
LIQLGSVEEA
540
IQALIELHNH
550
DLGENHHLRV
SFSKSTI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0043249 |
erythrocyte maturation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0033119 |
negative regulation of RNA splicing |
| Biological Process |
GO:0045595 |
regulation of cell differentiation |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.