Search Results
Overview
| Uniprot ID | A0A288CFU9 |
|---|---|
| Protein Name | tRNA-dihydrouridine(47) synthase [NAD(P)(+)] |
| Gene Name | DUS3L |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | REEPQVQKRARGQNK |
| 416 | ALMNRSAKFQQIVRG |
Function
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation
Protein Sequence
10
MAEGAAEAPA
20
ESGGGGGGGN
30
PGAGEPERGV
40
TPIKSQYLTT
50
KEQFHEFLEA
60
KGREEPSQET
70
KAGDPDDNDL
80
VEPEAKRIRL
90
EDGQTKDGQT
100
EEAAEQREEP
110
QVQKRARGQN
120
KSRPHVKPTH
130
YDKNRLCPSL
140
IQESASKCFY
150
GDRCRFLHDV
160
SLYLETKPAD
170
LGPRCVLFET
180
FGRCPYGVTC
190
RFAGAHLGPE
200
GQNLVQEGLV
210
QAPNIRNGLD
220
KALQQQLRKR
230
KVCFERSEQA
240
LRQLSKGRLP
250
GPTPTAAEPE
260
VTEADGAPEQ
270
DGCDAQQASH
280
GNAPPSGPLR
290
TCGPLTDEDV
300
VRLRPCEKRR
310
LDISGKLYLA
320
PLTTCGNLPF
330
RRICKRFGAD
340
VTCGEMAVCT
350
NLLQGQTSEW
360
ALLKRHPCED
370
VFGVQLEGAF
380
PDTMTKCAEL
390
LNRTIEVDFV
400
DINVGCPIDL
410
VYKKGGGCAL
420
MNRSAKFQQI
430
VRGMNQVLDV
440
PLTVKIRTGV
450
QERVNLAHRL
460
LPELRDWGAA
470
LVTLHGRSRE
480
QRYTKLADWQ
490
YIEQCVTAAS
500
PMPLFGNGDI
510
LSYEDANRAM
520
KTGVAGIMIA
530
RGALLKPWLF
540
TEIKEQRHWD
550
ISSSERLDIL
560
RDFTHYGLEH
570
WGSDTQGVEK
580
TRRFLLEWLS
590
FLCRYVPVGL
600
LERLPQRINE
610
RPPYYMGRDY
620
LETLMASQKA
630
ADWIRISEML
640
LGPVPPTFVF
650
LPKHKANAYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0106414 | mRNA dihydrouridine synthase activity |
| Molecular Function | GO:0017150 | tRNA dihydrouridine synthase activity |
| Molecular Function | GO:0102265 | tRNA-dihydrouridine47 synthase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0006417 | regulation of translation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.