Search Results
Overview
| Uniprot ID | A0A288CG58 |
|---|---|
| Protein Name | Glia-derived nexin |
| Gene Name | SERPINE2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | RFQPENTKKRTFVAA |
| 242 | AVAQTDLKEPLKVLG |
| 263 | PSKANFAKITRSENL |
| 280 | SHILQKAKIEVSEDG |
| 34 | KVLKKINKAIVSKKN |
Function
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin
Protein Sequence
10
MLQLGADGRT
20
KKQLTTVMRY
30
GVNGVGKVLK
40
KINKAIVSKK
50
NKDIVTVANA
60
VFVKNGFKME
70
VPFVTRNKDV
80
FQCEVRNADF
90
EDPASACDSI
100
NLWVRNETRG
110
MIDSLLSPDL
120
LDSVLTRLVL
130
VNAVYFKGLW
140
KSRFQPENTK
150
KRTFVAADGK
160
SYQVPMLAQL
170
SVFRCGSTST
180
PSDLWYNFIE
190
LPYHGESISM
200
LIALPTESST
210
PLSAIIPHIS
220
TKTIDSWMST
230
MVPKRVQVIL
240
PKFTAVAQTD
250
LKEPLKVLGV
260
TEMFDPSKAN
270
FAKITRSENL
280
HVSHILQKAK
290
IEVSEDGTKA
300
SAATTAILIA
310
RSSPPWFIVD
320
RPFLFFIRHN
330
PTGAVLFMGQ
INNPEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0007399 | nervous system development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.