Overview
| Uniprot ID | A0A2C9F350 |
|---|
| Protein Name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 296 |
RALDEATKYALERKT |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16
Protein Sequence
10
MNVVQVLRSL
20
SHFGWRSQHT
30
KAVPQCEPGS
40
GFSFELTEQQ
50
KEFQATARKF
60
AREEIIPVAA
70
EYDRTGEYPV
80
PLLKRAWELG
90
LMNTHIPESF
100
GGLGLGIIDS
110
CLITEELAYG
120
CTGVQTAIEA
130
NTLGQVPLII
140
GGNYQQQKKY
150
LGRMTEEPLM
160
CAYCVTEPGA
170
GSDVAGIKTK
180
AEKKGDEYII
190
NGQKMWITNG
200
GKANWYFLLA
210
RSDPDPKAPA
220
SKAFTGFIVE
230
ADTPGVQIGR
240
KEINMGQRCS
250
DTRGIVFEDV
260
RVPKENVLTG
270
EGAGFKIAMG
280
TFDKTRPPVA
290
AGAVGLAQRA
300
LDEATKYALE
310
RKTFGKLLAE
320
HQGISFLLAD
330
MAMKVELARL
340
SYQRAAWEID
350
SGRRNTYYAS
360
IAKAYAADIA
370
NQLATDAVQV
380
FGGNGFNTEY
390
PVEKLMRDAK
400
IYQIYEGTAQ
410
IQRIIIAREH
IGRYKN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0070991 |
medium-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process |
GO:0051791 |
medium-chain fatty acid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.