Search Results
Overview
| Uniprot ID | A0A2C9F366 |
|---|---|
| Protein Name | Heat shock protein beta-1 |
| Gene Name | HSPB1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | APEELTVKTKDGVVE |
| 140 | EELTVKTKDGVVEIT |
| 149 | GVVEITGKHEERQDE |
| 224 | LGGTEAGKSEKPGTK |
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins
Protein Sequence
10
MWAGPPSPRP
20
APRRSRTRPA
30
SAASMTERRV
40
PFSLLRSPSW
50
DPFRDWYPAH
60
SRLFDQAFGL
70
PRLPEEWSQW
80
LSHSGWPGYV
90
RPLPPPAIEG
100
PAAVAAPAYS
110
RLLSRQLSSG
120
VSEIQQTADR
130
WRVSLDVNHF
140
APEELTVKTK
150
DGVVEITGKH
160
EERQDEHGFI
170
SRCFTRKYTL
180
PPGVDPTQVS
190
SSLSPEGTLS
200
VEAPLPKPAT
210
QSAEITIPVT
220
FEARAQLGGT
230
EAGKSEKPGT
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0008426 | protein kinase C inhibitor activity |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:0060729 | intestinal epithelial structure maintenance |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090038 | negative regulation of protein kinase C signaling |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.