Search Results
Overview
| Uniprot ID | A0A2C9F389 |
|---|---|
| Protein Name | Large proline-rich protein BAG6 |
| Gene Name | BAG6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 56 | SVSIPSEKQRLIYQG |
Function
Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2)
Protein Sequence
10
MEPNDSTSTT
20
MEEPESLEVL
30
VKTLDSQTRT
40
FIVGAQMNVK
50
EFKEHIAASV
60
SIPSEKQRLI
70
YQGRVLQDDK
80
KLQEYNVGGK
90
VIHLVERAPP
100
QTQLPSGASS
110
GTGSASATHG
120
GGPPPGTRGP
130
GASVHDRNAN
140
SYVMVGTFNL
150
PSDGSAVDVH
160
INMEQAPIQS
170
EPRVRLVMAQ
180
HMIRDIQTLL
190
SRMECRGGSQ
200
AQHSQPPSQM
210
PTVAPEPVAL
220
SSQTSESVES
230
EVPPREPMAA
240
EEVEERASAQ
250
SPGLSSGPAP
260
AGPTPAPETN
270
APNHPSPAEY
280
VEVLQELQRL
290
ESRLQPFLQR
300
YYEVLGAAAT
310
TDYNNNQEGR
320
EEDQRLINLV
330
GESLRLLGNT
340
FVALSDLRCN
350
LACAPPRHLH
360
VVRPMSHYTT
370
PMVLQQAAIP
380
IQINVGTTVT
390
MTGNGTRPPP
400
TPNAEAPPPG
410
PGQASSLAPS
420
STTVESSTEG
430
APPPGPAPPP
440
AASHPRVIRI
450
SHQSVEPVVM
460
MHMNIQDSGT
470
QPGGVPSAPT
480
GPLGPTGHGQ
490
TLGSTLIQLP
500
SLPPEFMHAV
510
AHQITHQAMV
520
AAVASAAAGQ
530
QVPGFPTAPT
540
RVVIARPTPP
550
QSRPSHPGGP
560
PVSGALPGAG
570
LGTNASLAQM
580
VSGLVGQLLM
590
QPVLVAQGTP
600
GMAPPPAPAT
610
ASASAGTTNT
620
ATTAGPAPGG
630
PAQPPPPQPS
640
ASDLQFSQLL
650
GNLLGPAGPG
660
AGGPGMTSPT
670
ITVAMPGVPA
680
FLQGMTDFLQ
690
ATQTAAPPAP
700
PPPPPPPPPA
710
PEQQTAPPPG
720
SPPGGAGSPG
730
GLGPESLPLE
740
FFTSVVQGVL
750
SSLLGSLGAR
760
AGSSESIAAF
770
IQRLSGSSNI
780
FEPGADGALG
790
FFGALLSLLC
800
QNFSMVDVVM
810
LLHGHFQPLQ
820
RLQPQLRSFF
830
HQHYLGGQEP
840
TPGNIRTATH
850
TLITGLEEYV
860
RESFSLVQVQ
870
PGVDIIRTNL
880
EFLQEQFNSI
890
AAHVMHCTDS
900
GFGARLLELC
910
NQGLFECLAL
920
NLHCLGGQQM
930
ELAAVINGRI
940
RRMSRGVNPS
950
LVSWLTTMMG
960
LRLQVVLEHM
970
PVGPDAILRY
980
VRRVGDPPQP
990
LPEEPMEVQG
1000
SERTSPEPQR
1010
ENASPAPGTT
1020
AEEAMSRGPP
1030
PAPEGGSRDE
1040
QDGAAAETEP
1050
WAAAVPPEWV
1060
PIIQQDIQSQ
1070
RKVKPQPPLS
1080
DAYLSGMPAK
1090
RRKTMQGEGP
1100
QLLLSEAVSR
1110
AAKAAGARPL
1120
TSPESLSRDL
1130
EAPEVQESYR
1140
QQLRADIQKR
1150
LQEDPNYSPQ
1160
RFPNAHRAFA
EDP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071818 | BAT3 complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0051787 | misfolded protein binding |
| Molecular Function | GO:0031593 | polyubiquitin modification-dependent protein binding |
| Molecular Function | GO:0070628 | proteasome binding |
| Molecular Function | GO:0140597 | protein carrier chaperone |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:1990381 | ubiquitin-specific protease binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0061857 | endoplasmic reticulum stress-induced pre-emptive quality control |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0002429 | immune response-activating cell surface receptor signaling pathway |
| Biological Process | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0036506 | maintenance of unfolded protein |
| Biological Process | GO:0030101 | natural killer cell activation |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0051132 | NK T cell activation |
| Biological Process | GO:1904294 | positive regulation of ERAD pathway |
| Biological Process | GO:0006620 | post-translational protein targeting to endoplasmic reticulum membrane |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0007130 | synaptonemal complex assembly |
| Biological Process | GO:0071816 | tail-anchored membrane protein insertion into ER membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.