Search Results

Overview

Uniprot ID	A0A2C9F3E3
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
231	HYFPVMKKCCIPETR
318	REFILNLKKKECEEK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 MTLGREAMSP 20 LQAMSSYTVD 30 GRNVLRWDLS 40 PEQIKRRTEE 50 LIAQTKQVYD 60 DIGMLDIEEV 70 TYENCLQALA 80 DVEVKYIVER 90 TMLDFPQHVS 100 SDKEVRAAST 110 EADKRLSRFD 120 IEMSMREDIF 130 LRIVRLKETC 140 DLGKIKPEAR 150 RYLEKSVKMG 160 KRNGLHLPEQ 170 VQNEIKAMKK 180 RMSELCIDFN 190 KNLNEDDTFL 200 VFSKAELGAL 210 PDDFIDSLEK 220 TDDNKYKITL 230 KYPHYFPVMK 240 KCCIPETRRK 250 MEMAFNTRCK 260 EENTIILQEL 270 LPLRAKVAKL 280 LGYSTHADFV 290 LEMNTAKSTH 300 HVTAFLDDLS 310 QKLKPLGEAE 320 REFILNLKKK 330 ECEEKGFEYD 340 GKINAWDLHY 350 YMTQTEELKY 360 SVDQEILKEY 370 FPIEVVTEGL 380 LNIYQELLGL 390 SFEQVTDAHV 400 WNKSVTLYTV 410 KDKATGEVLG 420 QFYLDLYPRE 430 GKYNHAACFG 440 LQPGCLLPDG 450 SRMMSVAALV 460 VNFSQPRAGR 470 PSLLRHDEVR 480 TYFHEFGHVM 490 HQICAQTDFA 500 RFSGTNVETD 510 FVEVPSQMLE 520 NWVWDTDSLR 530 RLSKHYKDGS 540 PITDDLLEKL 550 VASRLVNTGL 560 LTLRQIVLSK 570 VDQSLHTNTS 580 LDAASEYAKY 590 CTEILGVAAT 600 PGTNMPATFG 610 HLAGGYDGQY 620 YGYLWSEVFS 630 MDMFYSCFKK 640 EGIMNPESHA 650 VEPALEPQHC 660 SASLSGVARV 670 PHHLSADALS 680 SLLRTLRSLE 690 VGMKYRNLIL 700 KPGGSLDGMD 710 MLQNFLKREP 720 NQKAFLMSRG LHAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.