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Overview

Uniprot IDA0A2C9F3H8
Protein NameLarge proline-rich protein BAG6
Gene NameBAG6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1067 EAVSRAAKAAGARPL
56 SVSIPSEKQRLIYQG

Function

Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2)

Protein Sequence

10 MEPNDSTSTT 20 MEEPESLEVL 30 VKTLDSQTRT 40 FIVGAQMNVK 50 EFKEHIAASV 60 SIPSEKQRLI 70 YQGRVLQDDK 80 KLQEYNVGGK 90 VIHLVERAPP 100 QTQLPSGASS 110 GTGSASATHG 120 GGPPPGTRGP 130 GASVHDRNAN 140 SYVMVGTFNL 150 PSDGSAVDVH 160 INMEQAPIQS 170 EPRVRLVMAQ 180 HMIRDIQTLL 190 SRMECRGGSQ 200 AQHSQPPSQM 210 PTVAPEPVAL 220 SSQTSESVES 230 EVPPREPMAA 240 EEVEERASAQ 250 SPGLSSGPAP 260 AGPTPAPETN 270 APNHPSPAEY 280 VEVLQELQRL 290 ESRLQPFLQR 300 YYEVLGAAAT 310 TDYNNNQEGR 320 EEDQRLINLV 330 GESLRLLGNT 340 FVALSDLRCN 350 LACAPPRHLH 360 VVRPMSHYTT 370 PMVLQQAAIP 380 IQINVGTTVT 390 MTGNGTRPPP 400 TPNAEAPPPG 410 PGQASSLAPS 420 STTVESSTEG 430 APPPGPAPPP 440 AASHPRVIRI 450 SHQSVEPVVM 460 MHMNIQDSGT 470 QPGGVPSAPT 480 GPLGPTGHGQ 490 TLGQQVPGFP 500 TAPTRVVIAR 510 PTPPQSRPSH 520 PGGPPVSGAL 530 PGAGLGTNAS 540 LAQMVSGLVG 550 QLLMQPVLVA 560 QGTPGMAPPP 570 APATASASAG 580 TTNTATTAGP 590 APGGPAQPPP 600 PQPSASDLQF 610 SQLLGNLLGP 620 AGPGAGGPGM 630 TSPTITVAMP 640 GVPAFLQGMT 650 DFLQATQTAA 660 PPAPPPPPPP 670 PPPAPEQQTA 680 PPPGSPPGGA 690 GSPGGLGPES 700 LPLEFFTSVV 710 QGVLSSLLGS 720 LGARAGSSES 730 IAAFIQRLSG 740 SSNIFEPGAD 750 GALGFFGALL 760 SLLCQNFSMV 770 DVVMLLHGHF 780 QPLQRLQPQL 790 RSFFHQHYLG 800 GQEPTPGNIR 810 TATHTLITGL 820 EEYVRESFSL 830 VQVQPGVDII 840 RTNLEFLQEQ 850 FNSIAAHVMH 860 CTDSGFGARL 870 LELCNQGLFE 880 CLALNLHCLG 890 GQQMELAAVI 900 NGRIRRMSRG 910 VNPSLVSWLT 920 TMMGLRLQVV 930 LEHMPVGPDA 940 ILRYVRRVGD 950 PPQPLPEEPM 960 EVQGSERTSP 970 EPQRENASPA 980 PGTTAEEAMS 990 RGPPPAPEGG 1000 SRDEQDGAAA 1010 ETEPWAAAVP 1020 PEWVPIIQQD 1030 IQSQRKVKPQ 1040 PPLSDAYLSG 1050 MPAKRRKTMQ 1060 GEGPQLLLSE 1070 AVSRAAKAAG 1080 ARPLTSPESL 1090 SRDLEAPEVQ 1100 ESYRQQLRAD 1110 IQKRLQEDPN 1120 YSPQRFPNAH RAFAEDP

Gene Ontology

Classification GO ID Description
Biological Process GO:0030154 cell differentiation
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005634 nucleus
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006325 chromatin organization
Biological Process GO:0002376 immune system process
Biological Process GO:0007283 spermatogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.