Overview
| Uniprot ID | A0A2I3JL00 |
|---|
| Protein Name | Sphingosine-1-phosphate transporter MFSD2B |
|---|
| Gene Name | MFSD2B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 443 |
SLEFSGYKAGVCKQA |
Function
Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology. Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation. Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate). Release of sphingosine-1-phosphate is facilitated by a proton gradient. In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport. In addition to export, also able to mediate S1P import. Does not transport lysophosphatidylcholine (LPC)
Protein Sequence
10
MAAPPAPAAK
20
GSPQPEPHAP
30
EPGPGSAKRG
40
REDSRAGRLS
50
FCTKVCYGIG
60
GVPNQIASSA
70
TAFYLQLFLL
80
DIAQIPAAQV
90
SLVLFGGKVS
100
GAAADPVAGF
110
FINRSQRTGS
120
GRLMPWVLGC
130
TPFIALAYFF
140
LWFLPPFTSL
150
RGLWYTTFYC
160
LFQALATFFQ
170
VPYTALTMLL
180
TPCPRERDSA
190
TAYRMTVEMA
200
GTLMGATVHG
210
LIVSGAHRPH
220
RCEATATPGP
230
VTVSPNAAHL
240
YCIAAAVVVV
250
TYPVCISLLC
260
LGVKERPDPS
270
APASGPGLSF
280
LAGLSLTTRH
290
PPYLKLVISF
300
LFISAAVQVE
310
QSYLVLFCTH
320
ASQLHDHVQG
330
LVLTVLVSAV
340
LSTPLWEWVL
350
QRFGKKTSAF
360
GIFAMVPFAI
370
LLAAVPTAPV
380
AYVVAFVSGV
390
SIAVSLLLPW
400
SMLPDVVDDF
410
QLQHRHGPGL
420
ETIFYSSYVF
430
FTKLSGACAL
440
GISTLSLEFS
450
GYKAGVCKQA
460
EEVVVTLKVL
470
IGAVPTCMIL
480
AGLCILMVGS
490
TPKTPSRDAS
SRLSLRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0046624 |
sphingolipid transporter activity |
| Molecular Function |
GO:0015293 |
symporter activity |
| Biological Process |
GO:0008643 |
carbohydrate transport |
Reference
PMID: N/A