Search Results
Overview
| Uniprot ID | A0A2R8Y619 |
|---|---|
| Protein Name | Histone H2B type 2-K1 |
| Gene Name | H2BK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | LLPGELAKHAVSEGT |
| 113 | HAVSEGTKAVTKYTS |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MSAEYGQRQQ
20
PGGRGGRSSG
30
NKKSKKRCRR
40
KESYSMYIYK
50
VLKQVHPDIG
60
ISAKAMSIMN
70
SFVNDVFEQL
80
ACEAARLAQY
90
SGRTTLTSRE
100
VQTAVRLLLP
110
GELAKHAVSE
120
GTKAVTKYTS
SK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006325 | chromatin organization |
Reference
PMID: N/A