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Overview

Uniprot IDA0A2X0TX35
Protein NameHistone H2B
Gene NameLOC123053409
OrganismTriticum aestivum

Kla Sites from experimental identification

Position Flanking peptide
43 EKRLPAGKTASKEGG

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MAPKAEKKPA 20 AKKPAEEEPA 30 AEKAEKAPAA 40 KKPKAEKRLP 50 AGKTASKEGG 60 EKKGKKKSKK 70 SVETYKIYIF 80 KVLKQVHPDI 90 GISSKAMSIM 100 NSFINDIFEK 110 LAGEAAKLAR 120 YNKKPTITSR 130 EIQTSVRLVL 140 PGELAKHAVS 150 EGTKAVTKFT SS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0006325 chromatin organization

Reference

[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.