Search Results
Overview
| Uniprot ID | A0A384N6C2 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | SRDIDFLKEEEHDCF |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MADYLISGGT
20
SYVPDDGLTA
30
QQLFNCGDGL
40
TYNDFLILPG
50
YIDFTADQVD
60
LTSALTKKIT
70
LKTPLVSSPM
80
DTVTEAGMAI
90
AMALTGGIGF
100
IHHNCTPEFQ
110
ANEVRKVKKY
120
EQGFITDPVV
130
LSPKDRVRDV
140
FEAKARHGFC
150
GIPITDTGRM
160
GSRLVGIISS
170
RDIDFLKEEE
180
HDCFLEEIMT
190
KREDLVVAPA
200
GITLKEANEI
210
LQRSKKGKLP
220
IVNEDDELVA
230
IIARTDLKKN
240
RDYPLASKDA
250
KKQLLCGAAI
260
GTHEDDKYRL
270
DLLAQAGVDV
280
VVLDSSQGNS
290
IFQINMIKYI
300
KDKYPNLQVI
310
GGNVVTAAQA
320
KNLIDAGVDA
330
LRVGMGSGSI
340
CITQEVLACG
350
RPQATAVYKV
360
SEYARRFGVP
370
VIADGGIQNV
380
GHIAKALALG
390
ASTVMMGSLL
400
AATTEAPGEY
410
FFSDGIRLKK
420
YRGMGSLDAM
430
DKHLSSQNRY
440
FSEADKIKVA
450
QGVSGAVQDK
460
GSIHKFVPYL
470
IAGIQHSCQD
480
IGAKSLTQVR
490
AMMYSGELKF
500
EKRTSSAQVE
510
GGVHSLHSYE
KRLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
| Biological Process | GO:0006177 | GMP biosynthetic process |
Reference
PMID: N/A