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Overview

Uniprot IDA0A3B5Y516
Protein NameHistone H2B
Gene Name-
OrganismTriticum aestivum

Kla Sites from experimental identification

Position Flanking peptide
14 KKPAAESKVEKAAEK
21 KVEKAAEKTPAGKKP

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MAPKADKKPA 20 AESKVEKAAE 30 KTPAGKKPKA 40 EKRLPAGKTA 50 SKEAGGEGKT 60 RGRKKGSKAK 70 KGVETYKIYI 80 FKVLKQVHPD 90 IGISSKAMSI 100 MNSFINDIFE 110 KLAGESAKLA 120 RYNKKPTITS 130 REIQTSVRLV 140 LPGELAKHAV 150 SEGTKAVTKF TSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0006325 chromatin organization

Reference

[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.