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Overview

Uniprot IDA0A3B5ZXW1
Protein NameDNA replication licensing factor MCM3
Gene NameLOC123182365
OrganismTriticum aestivum

Kla Sites from experimental identification

Position Flanking peptide
39 VRDMVQSKRHRLTIG

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity

Protein Sequence

10 MDVNEEAMAA 20 NKRAFLDFLD 30 QDVGKGVYMQ 40 AVRDMVQSKR 50 HRLTIGMDDL 60 RNHNLDLARR 70 VIRSPGEFMQ 80 PASDAVTEVA 90 RNLDPKFLKE 100 GERVLVGFTG 110 PFGFHRVTPR 120 DLMSSFIGTM 130 VCVEGIVTKC 140 SLVRPKVVKS 150 VHYCPATAAF 160 MSREYRDITS 170 FVGLPTGSVY 180 PTRDENGNLL 190 VTEYGMCQYK 200 DHQTLSMQEV 210 PENAAPGQLP 220 RTVDVIVEDD 230 LVDCCKPGDR 240 VSIVGLYKAL 250 PGKSKGSVSG 260 VFRTVLIANN 270 VSLLNKEANA 280 PVYTREDLKR 290 MKEISRRNDT 300 FDLLGNSLAP 310 SIYGHIWIKK 320 AVVLLMLGGV 330 EKNLKNGTHL 340 RGDINMMMVG 350 DPSVAKSQLL 360 RAVMNIAPLA 370 ISTTGRGSSG 380 VGLTAAVTSD 390 QETGERRLEA 400 GAMVLADRGV 410 VCIDEFDKMN 420 DQDRVAIHEV 430 MEQQTVTIAK 440 AGIHASLNAR 450 CSVIAAANPI 460 YGSYDRSITP 470 TKNIGLPDSL 480 LSRFDLLFIV 490 LDQMDAEIDR 500 QISEHVARMH 510 RYCADDGGAR 520 SFDKAGCAEE 530 EDGDANAAIF 540 VKYDRMLHGQ 550 DRRRGKKAKQ 560 DRLTIKFLKK 570 YIHYAKNLIQ 580 PRLTDEASDH 590 IATTYAELRD 600 GGANAKSGGG 610 TLPITARTLE 620 TIIRLSTAHA 630 KMKLRHEVLK 640 IDVEAALQVL 650 NFAIFHKELT 660 DMEDREQRAT 670 EKQQAEQDAG 680 ADGDNVDVPG 690 GASGGNADVH GSQTNVQWR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042555 MCM complex
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003678 DNA helicase activity
Biological Process GO:0006270 DNA replication initiation

Reference

[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.